| IED ID | IndEnz0002005979 |
| Enzyme Type ID | protease005979 |
| Protein Name |
Caspase-8 EC 3.4.22.61 Death-related ced-3/NEDD2-like protein Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10 |
| Gene Name | Dredd DCP2 CG7486 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MAGSNLLIHLDTIDQNDLIYVERDMNFAQKVGLCFLLYGDDHSDATYILQKLLAMTRSDFPQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITLHVHPLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSIKLGDINAAGSDVQLLVGHLKSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQQSYCSTQIDALKLTRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLIEVFSSMGYNVEAYDNVDHMGIIERIRSACDRSLVRDSLVVFILSHGFEEAVYASNSIAMKITDIEDLLCSYDTLYYKPKLLIIQACQEKLVHKKKPNELFRIDVTTVSPDQHIDMLRAMSTVNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNVKSTFRQHVYFPPRL |
| Enzyme Length | 494 |
| Uniprot Accession Number | Q8IRY7 |
| Absorption | |
| Active Site | ACT_SITE 345; /evidence=ECO:0000250; ACT_SITE 386; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).; EC=3.4.22.61; |
| DNA Binding | |
| EC Number | 3.4.22.61 |
| Enzyme Function | FUNCTION: Effector of the programmed cell death (PCD) activators rpr, grim and hid (PubMed:9740659). May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis (PubMed:10934188). Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection (PubMed:11269502). Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA (PubMed:22549468). {ECO:0000269|PubMed:10934188, ECO:0000269|PubMed:11269502, ECO:0000269|PubMed:22549468, ECO:0000269|PubMed:9740659}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (4); Chain (2); Erroneous initiation (1); Mutagenesis (2); Propeptide (2); Sequence conflict (2) |
| Keywords | Alternative splicing;Apoptosis;Cytoplasm;Hydrolase;Immunity;Innate immunity;Protease;Reference proteome;Thiol protease;Ubl conjugation;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10934188, ECO:0000269|PubMed:9740659}. |
| Modified Residue | |
| Post Translational Modification | PTM: Polyubiquitinated by Diap2 following activation of the immune deficiency (Imd) pathway. {ECO:0000269|PubMed:22549468}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10481910; 10511707; 10559939; 10559952; 10607561; 10684245; 10704400; 10898983; 10908589; 11048731; 11050334; 11139272; 11139274; 11139276; 11139278; 11139280; 11156609; 11178240; 11237461; 11252751; 11269501; 11283698; 11337470; 11337486; 11413042; 11485985; 11562344; 11606776; 11703941; 11724812; 11740492; 11742098; 11742401; 11872802; 11912489; 11951023; 11997504; 12006672; 12070100; 12072176; 12123572; 12176339; 12217523; 12364793; 12368087; 12401167; 12547518; 12563030; 12695332; 12728280; 12732719; 12938178; 12973300; 14603309; 14605208; 14722090; 14737191; 14744432; 15032585; 15037551; 15199954; 15199956; 15221030; 15314671; 15355784; 15573123; 15590702; 15621536; 15640802; 15860727; 15894191; 16081424; 16163390; 16170305; 16222340; 16399077; 16456582; 16485033; 16497588; 16763552; 16858400; 16890515; 16894030; 16980627; 17000765; 17050695; 17068333; 17166233; 17275304; 17341581; 17343912; 17417787; 17464325; 17475494; 17553907; 17588928; 17987029; 18000549; 18039869; 18056427; 18060786; 18066067; 18218863; 18309327; 18474356; 18688280; 18692774; 18775745; 18794330; 19046341; 19182545; 19224859; 19255589; 19497884; 19520911; 1963868; 19687202; 19740772; 19763182; 19822734; 19851448; 19893628; 19960024; 20100334; 20122400; 20137906; 20220848; 20371351; 20551040; 20600624; 20627393; 20719775; 21074052; 21120926; 21209287; 21338340; 21385866; 21664581; 21730059; 22118526; 22153373; 22238688; 22328149; 22368770; 22427641; 22450469; 22498775; 22539005; 22724070; 22824741; 22912810; 22949833; 23071443; 23124073; 23228366; 23261474; 23519152; 23523076; 23596533; 23680639; 23721820; 23749869; 23764256; 23781070; 23784845; 23810935; 23922788; 24012863; 24076361; 24120681; 24127584; 24154526; 24374974; 24380076; 24586180; 24598157; 24706930; 24891502; 2503417; 25115549; 25255315; 25312911; 25332163; 25421701; 25477468; 25530181; 25613379; 25668151; 25922346; 25931442; 25968339; 26134911; 26173873; 26213329; 26245905; 26391223; 26413413; 26434917; 26513145; 26824654; 26900934; 27058168; 27124581; 27128498; 27177021; 27357258; 27436552; 27974438; 28085885; 28102430; 28232220; 28264763; 28445733; 28455414; 28834743; 28945745; 29108998; 29146454; 29398649; 29522475; 29695493; 29752064; 29937377; 29942319; 30026495; 30119996; 30463009; 30684503; 31068592; 31080057; 31481676; 31543447; 31548372; 31566767; 31909714; 31969430; 32037698; 32521261; 32573699; 32656090; 32774336; 32839462; 33090185; 33358662; 33377870; 33476667; 33529757; 33598204; 33800390; 33863891; 33946849; 34010697; 34370736; 34463269; 9786886; 9916984; 9990849; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,153 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |