| IED ID | IndEnz0002005982 |
| Enzyme Type ID | protease005982 |
| Protein Name |
Caspase-8 EC 3.4.22.61 Death-related ced-3/NEDD2-like protein Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10 |
| Gene Name | Dredd GA20387 |
| Organism | Drosophila pseudoobscura pseudoobscura (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora obscura group pseudoobscura subgroup Drosophila pseudoobscura Drosophila pseudoobscura pseudoobscura (Fruit fly) |
| Enzyme Sequence | MSGHNILTQLESIDVLDLPYVERDLNFAQLVSLSFLLYGDEHSTATYILQKLLVLARATASDWPHSDILSQYAKSKPQTWRKYLVEALCIIGARQVLRKLGLCWQELRMHYLPHVGSIRVHIHPLLKSLYTICEELTLAQRGRMVLDIKEKNSVGDPLRFYDAEYLEIFLLDWLTRRLIRLGDFNANGSDVQLLIEYFKFNDLHAQATLLVDTVNAYATSSCSPATPNVLLPMDGNGIANESSSPTAAASRPRAKNALQLSRENAGIALIINQQEFYRDANDDYKVYLPPIELPLRNGTDMDKQRLTNVFSMLGYKVEAHDNLDHLSMLHHIRQACKRSLLHESLVVCILSHGFEDAVYGANSVALRISDIENVLCSYENLYEKPKLVVIQACQQEDKENNALPYKINASTKSPCQYLNMLRAMSTVPGFPALRHTQTGSWFIQSLCDAIVEHSNSDHIADILTIVINNVANKRGNKNETMVPWTGGALRQHVYFPRTSATDKVVPDSPGL |
| Enzyme Length | 511 |
| Uniprot Accession Number | Q29IM7 |
| Absorption | |
| Active Site | ACT_SITE 352; /evidence=ECO:0000250|UniProtKB:Q14790; ACT_SITE 393; /evidence=ECO:0000250|UniProtKB:Q14790 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).; EC=3.4.22.61; |
| DNA Binding | |
| EC Number | 3.4.22.61 |
| Enzyme Function | FUNCTION: Effector of the programmed cell death (PCD) activators rpr, grim and W. May play an apoptotic role in the germline as well as soma. Role in immune response, required to resist Gram-negative bacterial infections by regulating DptA. Fadd interacts with Dredd, Fadd promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. {ECO:0000250|UniProtKB:Q8IRY7}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (2); Erroneous gene model prediction (1); Propeptide (2) |
| Keywords | Apoptosis;Cytoplasm;Hydrolase;Immunity;Innate immunity;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14790}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 57,576 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |