| IED ID | IndEnz0002005985 |
| Enzyme Type ID | protease005985 |
| Protein Name |
Carboxypeptidase Q EC 3.4.17.- Plasma glutamate carboxypeptidase |
| Gene Name | cpq pgcp |
| Organism | Xenopus laevis (African clawed frog) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Anura Pipoidea Pipidae Xenopodinae Xenopus Xenopus Xenopus laevis (African clawed frog) |
| Enzyme Sequence | MKTLILTLLSLYELQLCCGAYNQNIRSQRKFEMIKTEISSYKDVAKSIIDLAVHGKAQNRSYERLALFVDTVGNRMSGSENLKTAIAYMYKSLQEDDLDRVYLEPVKVPHWERGEESAMLLEPRKKSLAILGLGGSIGTPVEGISAEVIVVSSFAELHNRSKEAKGKIVVYNEPFVNYGETVRYRGSGAVEAAKVGAVASLIRSVTPLSVYSPHTGWQWYENDVPKIPTASITVEDAEMLSRMASRGLKIVIQLKMGAVNHPDADSYNTVAEIVGSKYPEQVVIVSGHLDSWDVGQGAMDDGGGAFISWEALSLIKDLGLRPKRTLRLVLWTGEEQGGVGASQYYELHKKNISNIDLVMESDIGTFMPLGMQFTGKPEARAIMTEVMQLLQPINITSLYDYAEGTDINSWMQAGVPGASLFDDISKYFWFHHSQGDTMTVQDPVWMNLCAAVWTVVSYVVADMEEMLPR |
| Enzyme Length | 469 |
| Uniprot Accession Number | Q6GQ29 |
| Absorption | |
| Active Site | ACT_SITE 334; /note=Nucleophile; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.17.- |
| Enzyme Function | FUNCTION: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes more efficiently the hydrolysis of dipeptides with unsubstituted terminals into amino acids (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (4); Metal binding (6); Propeptide (1); Signal peptide (1) |
| Keywords | Carboxypeptidase;Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Hydrolase;Lysosome;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Lysosome {ECO:0000250}. Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 52,016 |
| Kinetics | |
| Metal Binding | METAL 288; /note=Zinc 1; /evidence=ECO:0000250; METAL 300; /note=Zinc 1; /evidence=ECO:0000250; METAL 300; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 335; /note=Zinc 2; catalytic; /evidence=ECO:0000250; METAL 362; /note=Zinc 1; /evidence=ECO:0000250; METAL 432; /note=Zinc 2; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |