| IED ID | IndEnz0002006031 |
| Enzyme Type ID | protease006031 |
| Protein Name |
Cathepsin B-like cysteine proteinase 2 EC 3.4.22.- |
| Gene Name | AC-2 |
| Organism | Haemonchus contortus (Barber pole worm) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Strongylida Trichostrongyloidea Haemonchidae Haemonchus Haemonchus contortus (Barber pole worm) |
| Enzyme Sequence | MKYLVLALCTYLCSQSGADENAAQGIPLEAQRLTGEPLVAYLRRSQNLFEVNSDPTPDFEQKIMSIKYKHQKLNLMVKEDPDPEVDIPPSYDPRDVWKNCTTFYIRDQANCGSCWAVSTAAAISDRICIASKAEKQVNISATDIMTCCRPQCGDGCEGGWPIEAWKYFIYDGVVSGGEYLTKDVCRPYPIHPCGHHGNDTYYGECRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQSVKAIQSEILKNGPVVASFAVYEDFRHYKSGIYKHTAGELRGYHAVKMIGWGNENNTDFWLIANSWHNDWGEKGYFRIVRGSNDCGIEGTIAAGIVDTESL |
| Enzyme Length | 342 |
| Uniprot Accession Number | P25793 |
| Absorption | |
| Active Site | ACT_SITE 114; /evidence=ECO:0000250; ACT_SITE 285; /evidence=ECO:0000250; ACT_SITE 305; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Expression of the protease correlates with blood-feeding and suggests a role for the protease in blood digestion. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (6); Glycosylation (4); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 38,407 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |