| IED ID | IndEnz0002006043 |
| Enzyme Type ID | protease006043 |
| Protein Name |
Exfoliative toxin B EC 3.4.21.- Epidermolytic toxin B |
| Gene Name | etb |
| Organism | Staphylococcus aureus |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus aureus |
| Enzyme Sequence | MDKNMFKKIILAASIFTISLPVIPFESTLQAKEYSAEEIRKLKQKFEVPPTDKELYTHITDNARSPYNSVGTVFVKGSTLATGVLIGKNTIVTNYHVAREAAKNPSNIIFTPAQNRDAEKNEFPTPYGKFEAEEIKESPYGQGLDLAIIKLKPNEKGESAGDLIQPANIPDHIDIQKGDKYSLLGYPYNYSAYSLYQSQIEMFNDSQYFGYTEVGNSGSGIFNLKGELIGIHSGKGGQHNLPIGVFFNRKISSLYSVDNTFGDTLGNDLKKRAKLDK |
| Enzyme Length | 277 |
| Uniprot Accession Number | P09332 |
| Absorption | |
| Active Site | ACT_SITE 96; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083; ACT_SITE 145; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083; ACT_SITE 217; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS). {ECO:0000269|PubMed:2117445, ECO:0000269|PubMed:2384148}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (12); Chain (1); Helix (8); Signal peptide (1); Turn (6) |
| Keywords | 3D-structure;Direct protein sequencing;Hydrolase;Plasmid;Protease;Serine protease;Signal;Toxin;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..31 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 1DT2; 1QTF; |
| Mapped Pubmed ID | 10441117; |
| Motif | |
| Gene Encoded By | Plasmid pRW001 |
| Mass | 30,765 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |