IED Industry Enzyme Database

Detail Information for IndEnz0002006083
IED ID IndEnz0002006083
Enzyme Type ID protease006083
Protein Name Mannose-binding protein C
MBP-C
Collectin-1
MBP1
Mannan-binding protein
Mannose-binding lectin
Gene Name MBL2 COLEC1 MBL
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
Enzyme Length 248
Uniprot Accession Number P11226
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. {ECO:0000269|PubMed:14515269}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (7); Chain (1); Coiled coil (1); Disulfide bond (2); Domain (2); Helix (4); Modified residue (5); Natural variant (5); Region (1); Signal peptide (1)
Keywords 3D-structure;Calcium;Coiled coil;Collagen;Complement activation lectin pathway;Complement pathway;Direct protein sequencing;Disulfide bond;Hydroxylation;Immunity;Innate immunity;Lectin;Mannose-binding;Reference proteome;Repeat;Secreted;Signal
Interact With P02743; P02749; P27797; P17927; Q9UGM3; Q07954; P48740-1; P48740-2; P48740-3; P48740; O00187; O00187-2; O00187; Itself; P10124; O00206; Q9UHD9; P27958; P9WQP3; P9WQP1
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7982896}.
Modified Residue MOD_RES 47; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:7982896; MOD_RES 73; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:7982896; MOD_RES 79; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:7982896; MOD_RES 82; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:7982896; MOD_RES 88; /note=Hydroxyproline; /evidence=ECO:0000269|PubMed:7982896
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000269|PubMed:7982896
Structure 3D X-ray crystallography (1)
Cross Reference PDB 1HUP;
Mapped Pubmed ID 10524686; 10528874; 10639434; 10925294; 11023480; 11145046; 11196679; 11196698; 11255386; 11274270; 11295122; 11302870; 11361219; 11393663; 11402450; 11487077; 11532276; 11712863; 11737072; 11781711; 11891230; 11906616; 11940329; 11986203; 12047967; 12370377; 12375325; 12393699; 12396008; 12439623; 12472676; 12485445; 12492252; 12517417; 12560567; 12595908; 12640191; 12641410; 12648279; 12651071; 12672193; 12699957; 12715245; 12761563; 12847552; 12918709; 12921293; 12934195; 12957407; 14280442; 14564351; 14582818; 14669753; 14732744; 14739370; 14764589; 14994386; 15061663; 15101708; 15127191; 15144709; 15148337; 15161763; 15199963; 15249448; 15254284; 15292002; 15295097; 15306844; 15381182; 15381817; 15467537; 15472209; 15480986; 15488604; 15516675; 15535834; 15627619; 15645196; 15647440; 15653690; 15674393; 15697204; 15723707; 15728497; 15730518; 15742161; 15753758; 15790942; 15829288; 15829302; 15838797; 15853952; 15855341; 15857180; 15888042; 15989776; 16006058; 16029433; 16034120; 16046196; 16099048; 16099912; 16102832; 16105157; 16110781; 16112196; 16115848; 16152689; 16170752; 16178865; 16185324; 16200716; 16208516; 16214215; 16216673; 16220211; 16231358; 16256117; 16320344; 16369192; 16385451; 16385529; 16429424; 16439442; 16476012; 16500704; 16517152; 16522396; 16553818; 16677572; 16681863; 16721783; 16729310; 16738667; 16750996; 16751976; 16792667; 16801331; 16827883; 16856624; 16911830; 16912583; 16916656; 16951387; 16953214; 16955210; 16960176; 17044201; 17045187; 17071626; 17072973; 17083310; 17083312; 17092257; 17096357; 17133182; 17157384; 17174748; 17178888; 17195187; 17202308; 17222001; 17259116; 17266113; 17275645; 17289451; 17303612; 17311505; 17314117; 17337399; 17357060; 17380431; 17415991; 17439930; 17442667; 17442954; 17470593; 17478467; 17480019; 17482281; 17484222; 17496053; 17513174; 17552055; 17554527; 17559949; 17565323; 17567900; 17610319; 17610322; 17626901; 17634432; 17651383; 17652092; 17653692; 17659761; 17665457; 17678865; 17703412; 17763324; 17845414; 17846289; 17848669; 17855170; 17869647; 17872904; 17875183; 17896801; 17898783; 17921115; 17922403; 17942155; 17942372; 17990579; 18031556; 18052966; 18082567; 18091754; 18166320; 18174230; 18177377; 18192915; 18194386; 18209939; 18211540; 18214570; 18221301; 18231631; 18288881; 18292811; 18317236; 18322223; 18334024; 18336595; 18347304; 18348874; 18361935; 18361938; 18368489; 18374983; 18396436; 18400978; 18415846; 18452612; 18455525; 18478332; 18486762; 18494378; 18495592; 18496832; 18498240; 18543229; 18552214; 18562462; 18582923; 18592362; 18602571; 18602696; 18611155; 18612667; 18633131; 18637104; 18637753; 18641104; 18676680; 18700861; 18715406; 18727690; 18729778; 18782274; 18818748; 18823346; 18831943; 18847375; 18927129; 18936436; 18950864; 18952132; 18957309; 18988385; 19019335; 19021583; 19035512; 19050632; 19056797; 19057812; 19064572; 19073229; 19083122; 19086549; 19094203; 19104434; 19139195; 19143554; 19169708; 19170196; 19185543; 19199550; 19238444; 19252378; 19258923; 19273450; 19275921; 19276308; 19286845; 19307021; 19328949; 19336370; 19344414; 19352197; 19366862; 19371855; 19380618; 19408100; 19416237; 19423540; 19425063; 19430499; 19432958; 19465640; 19466271; 19467940; 19468207; 19477015; 19480845; 19481774; 19501100; 19517215; 19527514; 19540295; 19557622; 19580835; 19590686; 19606686; 19625176; 19657091; 19692168; 19703233; 19709662; 19711212; 19715891; 19716183; 19729601; 19738092; 19775369; 19789190; 19790141; 19796526; 19796822; 19804807; 19817957; 19827946; 19833760; 19840833; 19853314; 19854517; 19879913; 19891773; 19913121; 19917506; 19939454; 19959685; 19969625; 20022898; 20038440; 20042521; 20056178; 20065005; 20068595; 20078874; 20079790; 20087947; 20110521; 20127985; 20132924; 20140243; 20150204; 20172753; 20193030; 20196868; 20207250; 20237496; 20298391; 20331378; 20331735; 20334849; 20351616; 20356797; 20374367; 20406964; 20408832; 20438785; 20442634; 20443743; 20452482; 20453525; 20463618; 20499118; 20503287; 20504205; 20522590; 20570631; 20573835; 20592033; 20593422; 20595266; 20598754; 20605050; 20610664; 20618520; 20628086; 20636396; 20642202; 20650301; 20673868; 20682603; 20688922; 20693349; 20712489; 20712490; 20732365; 20799037; 20833838; 20848568; 20881011; 20887383; 20930093; 21045008; 21054788; 21054877; 21088049; 21091907; 21106539; 21142772; 21171930; 21182784; 21192229; 21194488; 21203938; 21211797; 21281477; 21327568; 21334396; 21394075; 21496252; 21510992; 21536088; 21544638; 21554230; 21557458; 21592999; 21640628; 21655939; 21681178; 21702710; 21707593; 21722964; 21729275; 21733090; 21893516; 21895981; 21911261; 21920399; 21974696; 22002015; 22022564; 22050689; 22050925; 22082351; 22118625; 22131319; 22134613; 22172537; 22173059; 22183303; 22206649; 22215653; 22221294; 22225939; 22247351; 22258234; 22282660; 22296677; 22301353; 22302853; 22331020; 22335808; 22360648; 22363494; 22377282; 22380611; 22444663; 22512728; 22523362; 22578937; 22607836; 22633170; 22650645; 22673492; 22674410; 22762710; 22774989; 22813781; 22820623; 22848725; 22882323; 22938690; 22974720; 22994203; 23000376; 23000377; 23062612; 23065234; 23073041; 23094532; 23172101; 23225056; 23246423; 23289185; 23348713; 23417614; 23423485; 23439277; 23448728; 23524205; 23563916; 23592124; 23602874; 23637788; 23662819; 23711995; 23741476; 23750697; 23806468; 23861212; 23865867; 23911397; 24035792; 24047736; 24086711; 24103065; 24116040; 24118442; 24126531; 24134411; 24182802; 24227370; 24255984; 24264011; 24321303; 24321858; 24338257; 24339961; 24376633; 24391218; 24391778; 24399838; 24429128; 24453114; 24472859; 24530528; 24579967; 24593307; 24595015; 24601758; 24602163; 24691546; 24751721; 24753481; 24771334; 24798938; 24810526; 24819208; 24825317; 24850777; 24856568; 24861434; 24877121; 24886325; 24901869; 24910008; 24952212; 24972325; 25019352; 25024112; 25038892; 25060516; 25083730; 25105751; 25119337; 25143944; 25148801; 25167768; 25170052; 25178872; 25281004; 25312983; 25313559; 25323207; 25326706; 25341475; 25350077; 25599785; 25627044; 25693844; 25725598; 25787238; 25803807; 25818534; 25830474; 25843194; 25857450; 25879044; 25887173; 25900955; 25956563; 25969530; 26136138; 26153116; 26207622; 26212019; 26297290; 26377840; 26382056; 26429318; 26433879; 26506729; 26603976; 26613217; 26684757; 26740328; 26745156; 26795763; 26810288; 26823854; 26857650; 26924055; 27124763; 27136459; 27141819; 27180198; 27183610; 27223255; 27298104; 27351742; 27404661; 27424141; 27495980; 27557564; 27590640; 27624657; 27755461; 27798151; 27812036; 27820718; 27856789; 27876780; 27894112; 27911110; 27940354; 27982280; 28032346; 28056798; 28189510; 28403045; 28405017; 28408790; 28558032; 28576308; 28649744; 28706259; 28784323; 28898115; 29053425; 29120581; 29298876; 29314753; 29439276; 29627640; 29653582; 29703608; 29775825; 29807983; 29850562; 29886784; 29902796; 30015228; 30290772; 30482213; 30482481; 30526728; 30710628; 30907154; 30967869; 30999018; 31001794; 31012247; 31139182; 31332999; 31411530; 31446139; 31549610; 31578522; 31703823; 31706269; 31941497; 32119194; 32269261; 32279906; 32349793; 32616614; 32635881; 32721184; 32894076; 32894840; 32913345; 33013845; 33146461; 33180387; 33262767; 33270011; 33362211; 33515713; 33627253; 33679736; 34391418; 34480982; 34628288; 6019133; 70787;
Motif
Gene Encoded By
Mass 26,144
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda