| IED ID | IndEnz0002006112 |
| Enzyme Type ID | protease006112 |
| Protein Name |
Virulence-related protein Nf314 EC 3.4.16.- |
| Gene Name | |
| Organism | Naegleria fowleri (Brain eating amoeba) |
| Taxonomic Lineage | cellular organisms Eukaryota Discoba Heterolobosea Tetramitia Eutetramitia Vahlkampfiidae Naegleria Naegleria fowleri (Brain eating amoeba) |
| Enzyme Sequence | MMMRCVNGQTAQDHLVTQLPGLSGNIGVKSYTGYLLANATRGRYLFYWFFESMRNPSQDPLVMWTNGGPGCSSLGGEASEHGLFLVNADGATITRNPYSWNRVSNILYIEQPVGVGFSYSNSTDDYQNLNDVQAASDMNNALRDFLTRFPQFIGRETYLAGESYGGVYVPTTAYNIVEGNGKGQQPYVNLVGILVGNGVTDAEADSNSIPPMMKYHSLISIKYYEEGYKACQGDFYANQNLPACQKFLTDSSNAMGNINPYYIYDSCPWLGINLQQKLKTTQEMTFQVLDPKTQQPVKIHPLFQMYKHGGWSKRVANERNFAPRFETDAPCVPNQSIAKYFRRLDVQQALGVRRKTADPNGWNICTGIINYTQVYSTILPFYAKLLPHIRILVYSGDTDMVVNGLGTQAAIDKLQLQETSSWRTWEFDSALGTVVGGYIRKFEKSGKGLTFITVRGAGHMVPLVKPDSAFYMFKNFIDGTCC |
| Enzyme Length | 482 |
| Uniprot Accession Number | P42661 |
| Absorption | |
| Active Site | ACT_SITE 163; /evidence=ECO:0000250; ACT_SITE 399; /evidence=ECO:0000250; ACT_SITE 459; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.16.- |
| Enzyme Function | FUNCTION: May be required but is not sufficient for increased virulence. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | Carboxypeptidase;Hydrolase;Protease |
| Interact With | |
| Induction | INDUCTION: By growth on mammalian cells. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 53,848 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |