| IED ID | IndEnz0002006161 |
| Enzyme Type ID | protease006161 |
| Protein Name |
B2 bradykinin receptor B2R BK-2 receptor |
| Gene Name | Bdkrb2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MPCSWKLLGFLSVHEPMPTAASFGIEMFNVTTQVLGSALNGTLSKDNCPDTEWWSWLNAIQAPFLWVLFLLAALENLFVLSVFFLHKNSCTVAEIYLGNLAAADLILACGLPFWAITIANNFDWVFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMREYSEEGHNVTACVIVYPSRSWEVFTNVLLNLVGFLLPLSVITFCTVRILQVLRNNEMKKFKEVQTERKATVLVLAVLGLFVLCWVPFQISTFLDTLLRLGVLSGCWDEHAVDVITQISSYVAYSNSGLNPLVYVIVGKRFRKKSREVYRVLCQKGGCMGEPVQMENSMGTLRTSISVERQIHKLQDWAGKKQ |
| Enzyme Length | 392 |
| Uniprot Accession Number | P32299 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Disulfide bond (1); Glycosylation (3); Lipidation (1); Modified residue (6); Sequence conflict (2); Topological domain (8); Transmembrane (7) |
| Keywords | Alternative splicing;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Lipoprotein;Membrane;Palmitate;Phosphoprotein;Receptor;Reference proteome;Transducer;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. |
| Modified Residue | MOD_RES 157; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 348; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 367; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 370; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 374; /note=Phosphoserine; by GRK6; /evidence=ECO:0000250|UniProtKB:P30411; MOD_RES 376; /note=Phosphoserine; by GRK6; /evidence=ECO:0000250|UniProtKB:P30411 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 44,389 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |