| IED ID | IndEnz0002006190 |
| Enzyme Type ID | protease006190 |
| Protein Name |
Metacaspase-5 AtMC5 EC 3.4.22.- Metacaspase 2b AtMCP2b Metacaspase-6 |
| Gene Name | AMC5 AMC6 MCP2B At1g79330 YUP8H12R.5 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MAKKAVLIGINYPGTKAELRGCVNDVRRVHKSLVDRFGFSERNITELIDTDESSTKPTGKNIRRALLNLVESAKPGDVLVVHYSGHGTRLPAETGEDDDTGYDECIVPCDMNLITDDEFRDLVEKVPKEAHITIISDSCHSGGLIDEAKEQIGESTKKKPKKESGGSSGLGIKGFVREAVEEALESKGIAIPHHKDEKDENKTKELKLEDGAKVHVVNKSLPLQTLIDILKQNTGNNDIEVGKIRPTLFNVFGEDASPKVKKFMKVILTKLQEGKTEGGILGMIGKLAQEFLKHKLNDDEEYVKPAMKTHVGNKQEVYAGASNGSLADNGILISGCQTDQTSADASPQGHPEMAYGAFTNAVQIILEETKGMITYKELVLKARKLLKKQGFSQRPGLYCSDSFVNAPFIC |
| Enzyme Length | 410 |
| Uniprot Accession Number | O64518 |
| Absorption | |
| Active Site | ACT_SITE 86; /evidence=ECO:0000250; ACT_SITE 139 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. May be involved in the modulation of programmed cell death activated by oxidative stress. {ECO:0000269|PubMed:15691845}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Modified residue (1); Mutagenesis (1) |
| Keywords | Autocatalytic cleavage;Hydrolase;Protease;Reference proteome;S-nitrosylation;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 139; /note=S-nitrosocysteine; /evidence=ECO:0000250|UniProtKB:Q9FYE1 |
| Post Translational Modification | PTM: Proteolytically processed; by an autocatalytic mechanism. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 18431481; 22112449; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,846 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |