| IED ID | IndEnz0002006193 |
| Enzyme Type ID | protease006193 |
| Protein Name |
Probable metallocarboxypeptidase A MCPA EC 3.4.17.- Carboxypeptidase M14A |
| Gene Name | MCPA TRV_07931 |
| Organism | Trichophyton verrucosum (strain HKI 0517) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Trichophyton verrucosum (Cattle ringworm fungus) Trichophyton verrucosum (strain HKI 0517) |
| Enzyme Sequence | MRSVLSLALLAVNVVTAAVVAPFDYSGYKVIRVPTQKDNVKEVQRIITDLNLDTWKYPKSEGQNADIVVPPSQISSFMERISGMNIEMMHEDLGLSIRNETSFEAYSAGYAPDINWFKSYHSYQDHLSYLQDLQGLFRTRSEYVDAGKSHEGRTIPALHIWGSGGKNSKPAIIFHGTIHAREWITTMVTEYMAWSFLSQYNKNADITSIVDNFDIWIFPIVNPDGFAFTQTSNRLWRKNRQPNPNARCPGRDLNRNYPYQWVGPGSSSNPCSDTYRGAQPGDGTEIKVHIANMKKIAANKGIAMFVDWHSYGQLFMSPYGYSCTARPPTDARHQELSRIFAQALKAVHGTPYKTGPICNTIYQVNGDSVDYALEVLKVKLSLTAELRDTGARGFVLPADQIIPSGEETLAGTVAMLKAVIQG |
| Enzyme Length | 422 |
| Uniprot Accession Number | D4DL57 |
| Absorption | |
| Active Site | ACT_SITE 385; /note=Nucleophile; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | BINDING 237; /note=Substrate; /evidence=ECO:0000250 |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.17.- |
| Enzyme Function | FUNCTION: Extracellular metalloprotease that contributes to pathogenicity. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Binding site (1); Chain (1); Disulfide bond (1); Metal binding (3); Propeptide (1); Region (3); Signal peptide (1) |
| Keywords | Carboxypeptidase;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Virulence;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,132 |
| Kinetics | |
| Metal Binding | METAL 179; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 182; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 309; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |