| IED ID | IndEnz0002006217 |
| Enzyme Type ID | protease006217 |
| Protein Name |
Inactive serine protease PAMR1 Peptidase domain-containing protein associated with muscle regeneration 1 Regeneration-associated muscle protease homolog |
| Gene Name | Pamr1 Ramp |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MELDRWAQLGLVFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECLCPGKKEVVGYTIPCCRNEDNECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGWYGGDCMRCGQVLRASKGQILLESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNERPAPIRSTGSSLHVLFHSDGSKNFDGFHAVFEEITACSSSPCFHDGTCLLDTTGSFKCACLAGYTGQRCENLLEERNCSDLGGPVNGYKKITEGPGLLNERHVKIGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVCMKACREPKISDLVRRRVLSMQVQSRETPLHQLYSTAFSKQKLQDASTKKPALPFGDLPPGYQHLHTQVQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIESTPSPKTQGTRWPWQAAIYRRTSGVHDGGLHKGAWFLVCSGALVNERTVVVAAHCVTELGKATIIKTADLKVVLGKFYRDDDRDEKSIQNLRVSAIILHPNYDPILLDTDIAVLKLLDKARISTRVQPICLATTRDLSTSFQESHITVAGWNILADVRSPGFKNDTLHYGMVRVVDPMLCEEQHEDHGIPVSVTDNMFCASKDPSTPSDICTAETGGIAALSFPGRASPEPRWHLVGLVSWSYDKTCSNGLSTAFTKVLPFKDWIERNMK |
| Enzyme Length | 720 |
| Uniprot Accession Number | Q8BU25 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May play a role in regeneration of skeletal muscle. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (11); Domain (5); Glycosylation (1); Sequence conflict (3); Signal peptide (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Reference proteome;Repeat;Secreted;Serine protease homolog;Signal;Sushi |
| Interact With | |
| Induction | INDUCTION: Down-regulated in dystrophin-mutant mdx muscle cell line. {ECO:0000269|PubMed:15111323}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12466851; 18554416; 20562862; 21267068; 21677750; 24006456; 26018251; 26944677; 32518939; |
| Motif | |
| Gene Encoded By | |
| Mass | 80,320 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |