IED Industry Enzyme Database

Detail Information for IndEnz0002006316
IED ID IndEnz0002006316
Enzyme Type ID protease006316
Protein Name Interstitial collagenase
EC 3.4.24.7
Fibroblast collagenase
Matrix metalloproteinase-1
MMP-1

Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase
Gene Name MMP1 CLG
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Enzyme Length 469
Uniprot Accession Number P03956
Absorption
Active Site ACT_SITE 219
Activity Regulation ACTIVITY REGULATION: Can be activated without removal of the activation peptide.
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.; EC=3.4.24.7; Evidence={ECO:0000269|PubMed:1645757, ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297, ECO:0000269|PubMed:2557822};
DNA Binding
EC Number 3.4.24.7
Enzyme Function FUNCTION: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). {ECO:0000269|PubMed:1645757, ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297, ECO:0000269|PubMed:2557822}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Beta strand (31); Chain (3); Disulfide bond (1); Glycosylation (1); Helix (10); Metal binding (24); Modified residue (3); Motif (1); Mutagenesis (1); Natural variant (6); Propeptide (1); Region (1); Repeat (4); Sequence conflict (7); Signal peptide (1); Site (2); Turn (5)
Keywords 3D-structure;Autocatalytic cleavage;Calcium;Collagen degradation;Direct protein sequencing;Disulfide bond;Extracellular matrix;Glycoprotein;Host-virus interaction;Hydrolase;Metal-binding;Metalloprotease;Phosphoprotein;Protease;Reference proteome;Repeat;Secreted;Signal;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2167156}.
Modified Residue MOD_RES 57; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:25171405; MOD_RES 274; /note=Phosphothreonine; /evidence=ECO:0000269|PubMed:25171405; MOD_RES 360; /note=Phosphotyrosine; by PKDCC; /evidence=ECO:0000269|PubMed:25171405
Post Translational Modification PTM: Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase. {ECO:0000269|PubMed:10092871}.; PTM: Tyrosine phosphorylated in platelets by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
Signal Peptide SIGNAL 1..19
Structure 3D NMR spectroscopy (4); X-ray crystallography (11)
Cross Reference PDB 1AYK; 1CGE; 1CGF; 1CGL; 1HFC; 1SU3; 2AYK; 2CLT; 2J0T; 2TCL; 3AYK; 3SHI; 4AUO; 4AYK; 966C;
Mapped Pubmed ID 10074939; 10353819; 10551873; 10706100; 10809722; 10842101; 10986281; 11104795; 11278729; 11381077; 11489811; 11528521; 11546917; 11577169; 11586041; 11691799; 11705862; 11751876; 11762702; 11824952; 11831026; 11836255; 11875051; 11918701; 11934016; 11960372; 12005449; 12009332; 12032154; 12034345; 12050187; 12054564; 12060661; 12071839; 12145314; 12177784; 12225803; 12229968; 12364729; 12379487; 12393408; 12432557; 12466191; 12473595; 12515907; 12517806; 12528113; 12572877; 12622858; 12651627; 12667140; 12676763; 12692352; 12706853; 12767235; 12784383; 12787920; 12788533; 12837283; 12845675; 12861139; 12873541; 12904296; 12949792; 12969782; 1311314; 13129650; 1326552; 1371271; 14499230; 14512169; 14515149; 14550555; 14550952; 14558091; 14581488; 14626631; 14659851; 14669348; 14679206; 14692651; 14705229; 14707126; 14707454; 14729059; 14730602; 14764579; 1480033; 14962105; 14982353; 14986114; 15116091; 15127970; 15142265; 15149160; 15182858; 15184373; 15194213; 15200479; 15257288; 15257748; 15274394; 15288123; 15288468; 15291299; 15308634; 15312099; 15319295; 15337261; 15350133; 15375490; 15383690; 15459390; 15467742; 15476622; 15499569; 15528217; 15534109; 15610507; 15612581; 15617836; 15638833; 15654517; 15654971; 15661214; 15688379; 15701845; 15707890; 15718477; 15728253; 15737206; 15754326; 15767330; 15804950; 15817699; 15818737; 15832405; 15855654; 15864312; 15866608; 15879464; 15930517; 15939478; 15944607; 15955221; 15957163; 15965045; 16076963; 16080875; 16098031; 16103692; 16191276; 16202315; 16205632; 16210018; 16210545; 16213873; 16214204; 16236134; 16248458; 16256416; 16267613; 16273295; 16278009; 16278291; 16288711; 16301860; 16302919; 16311244; 16321971; 16353148; 16356191; 16359987; 16386110; 16405530; 16410344; 16424284; 16453302; 16538639; 16569638; 16580524; 16606674; 16623785; 16638593; 16676616; 16681691; 16714289; 16739355; 16767672; 16767840; 16774538; 16825321; 16850107; 16877347; 16890240; 16899023; 16912186; 16921111; 16921115; 16937230; 16945025; 16967187; 16972255; 16972994; 1698775; 17000679; 17009408; 17033924; 17035633; 1704217; 17047378; 17050530; 17077200; 17109104; 17125518; 17145822; 17151781; 17178858; 17245132; 17303772; 17311017; 17316652; 17335808; 17339606; 17352267; 17363400; 17363767; 17373931; 17383306; 17429393; 17434489; 17441888; 17473191; 17475625; 17488873; 17502998; 17508023; 17537400; 17543340; 17558677; 17564313; 17572495; 17589947; 17599818; 17607721; 17611984; 17625450; 17663001; 17669621; 17697361; 17709546; 17714581; 17765638; 17893005; 17901377; 17919326; 17921324; 17980059; 17980449; 17986285; 17990358; 17996495; 18006768; 18006830; 18025061; 18025848; 18027871; 18028894; 18030675; 18035073; 18060744; 18089791; 18097620; 18164995; 18178580; 18194849; 18212480; 18259971; 18276095; 18298349; 18314110; 18323784; 18360703; 18366705; 18426080; 18439317; 18447576; 18449210; 18459971; 18468407; 18469853; 18472160; 18480665; 18483334; 18496696; 18503554; 18506448; 18508261; 18557930; 18565735; 18569608; 18586252; 18588890; 18597171; 18602909; 18617682; 18619044; 18619594; 18621744; 18625714; 18625914; 18634015; 18636124; 18674955; 18676680; 18705799; 18710412; 18719610; 1874716; 18755271; 18798060; 18802702; 18807561; 18818748; 18823886; 18835135; 18851945; 18852494; 18853190; 18952406; 18988801; 19006025; 19019335; 19020733; 19040577; 19054653; 19055644; 19056482; 19094243; 19099971; 19124156; 19132754; 19134348; 19170196; 19185846; 19188843; 19191136; 19197535; 19221176; 19243899; 19246282; 19279308; 19282863; 19293200; 19296842; 19302792; 19303106; 19307187; 19318431; 19321798; 19336370; 19345347; 19379698; 19381070; 19383080; 19398000; 19424605; 19427971; 19432148; 19435861; 19442604; 19464975; 19480010; 19489099; 19489686; 19497711; 19506087; 19507017; 19507256; 19508478; 19527514; 19542367; 19543729; 19550047; 19551141; 19551542; 19575982; 19577645; 19578796; 19584257; 19585142; 19590686; 19591174; 19602108; 19608765; 19610062; 19620856; 19625176; 19628284; 19634113; 19639194; 19643940; 19659894; 19661147; 19664242; 19681861; 19692168; 19708869; 19723873; 19734590; 19787068; 19789190; 19797822; 19821768; 19836620; 19843588; 19883500; 19885545; 19892918; 19901964; 19902888; 19906289; 19911067; 19913121; 19923455; 19951575; 19953231; 19963114; 20031604; 20038976; 20039537; 2005102; 20060194; 20078883; 20091096; 20095886; 20102637; 20111728; 20142769; 20160424; 20192597; 20201953; 20204402; 20219323; 20225236; 20357815; 20392358; 20423842; 20435584; 20437278; 20452482; 20452670; 20453000; 20455995; 20460098; 20463008; 20463013; 20467172; 20471133; 20483790; 20484597; 20485444; 20493732; 20517696; 20538124; 20565774; 20584750; 20587546; 20609440; 20616161; 20616708; 20617463; 20628086; 20628624; 20655738; 20662554; 20673868; 20701626; 20702488; 20706772; 20808730; 20813982; 20826916; 20827277; 20852404; 20855151; 20860530; 20873121; 20935575; 20971661; 20979817; 21039987; 21042785; 21055468; 21070736; 21108787; 21143918; 21144496; 21154774; 21161310; 21170377; 21224082; 21232745; 21241837; 21244504; 21244711; 21251748; 21277671; 21279994; 21336947; 21344389; 21345293; 21357403; 21382168; 21397653; 21410405; 21410539; 21424117; 21432777; 21451543; 21454617; 21481333; 21519144; 21523769; 21531813; 21539914; 21544886; 21547130; 21591259; 21606841; 21637818; 21640141; 21670150; 21672616; 21673681; 2169257; 21694466; 21707906; 21709637; 21715326; 2173606; 21753786; 21756063; 21757573; 21761103; 2176865; 21835023; 21835828; 21858729; 21872446; 21881840; 21909684; 21925842; 21935932; 21945315; 21948273; 21952248; 21964487; 21964541; 21966428; 21988832; 22005258; 22011282; 22024213; 22030392; 22092736; 22117411; 22177562; 22184992; 22198560; 22207289; 22253805; 22286923; 22323068; 22333608; 22341926; 22367096; 22369948; 22390030; 22401717; 22439866; 22442164; 22487523; 22515421; 22573325; 22580338; 22655095; 22683752; 22712305; 22761315; 22776467; 22788708; 22819245; 22851691; 22853432; 22868188; 22901654; 22922035; 22936257; 22965879; 22992122; 22992722; 22993337; 23060436; 23063352; 23064462; 23086340; 23098370; 23108733; 23116893; 23147541; 23155052; 23164104; 23217186; 23222305; 23239492; 23253141; 23313298; 23322779; 23343931; 23357697; 23370084; 23389922; 23418737; 23418792; 23441116; 23441173; 23485169; 23497408; 23500593; 23504324; 23509928; 23527212; 23555662; 23585206; 23601157; 23603351; 23608755; 23614742; 23639976; 23644699; 23644943; 23650722; 23653009; 23676485; 23687338; 23696797; 23705892; 23744893; 23762835; 23763354; 23776649; 23794948; 23800176; 23800300; 23814055; 23815085; 23819551; 23840483; 23849018; 23870768; 23873107; 23893803; 23900981; 23902766; 23929359; 23934131; 23935888; 23946168; 23967200; 23978194; 24001791; 24025334; 24058270; 24063540; 24075964; 24134675; 24202438; 24212294; 24268990; 24289089; 24293148; 24352036; 24390660; 24414606; 24442990; 24472657; 24479343; 24505358; 24505369; 24513266; 24587395; 24637763; 24743777; 24755160; 24760149; 24792232; 24805876; 24834994; 24843171; 24899116; 24959655; 24972610; 24973648; 24980707; 24995609; 25022892; 25043669; 25115393; 25148204; 25181017; 25201474; 25233933; 25234944; 25241761; 25253367; 25257555; 25263962; 25269045; 25291965; 25312481; 25319362; 2537292; 25372932; 25391421; 25391977; 2551898; 25527274; 25530657; 25549795; 25599395; 25605062; 25605938; 25635325; 25691572; 25704319; 25724359; 25725450; 25739290; 25747934; 25854159; 25863779; 25950130; 25977510; 26018933; 26074138; 26120586; 26130135; 26215578; 26260627; 26292968; 26301605; 26305549; 26363461; 26367274; 26510114; 26513020; 26600542; 26751737; 26782559; 26891870; 26900010; 26926305; 26960630; 26973196; 26995105; 27017522; 27060293; 27072559; 27130665; 27138044; 27173221; 27271323; 27313452; 27323171; 27354591; 27354592; 27378148; 27381606; 27412345; 27412967; 27418197; 27428613; 27556208; 27630193; 27653023; 27659332; 27659527; 27693213; 27706715; 27733582; 27754420; 27793533; 27797337; 27798872; 27884164; 27898420; 28002595; 28005267; 28008134; 28013036; 28068631; 28101856; 28119029; 28122331; 28129430; 28160256; 28238786; 28262727; 28262842; 28334049; 2834383; 28367737; 28387651; 28398769; 28447732; 2845110; 28497435; 28543681; 28551623; 28557373; 28577062; 28637905; 28683186; 28819304; 28944430; 28954603; 28958661; 28961241; 29044936; 29049163; 29096757; 29115452; 29122080; 29132384; 29215835; 29217529; 29249121; 29250654; 29263043; 29277780; 29290801; 29317790; 29358561; 29384216; 29428815; 29436615; 29458338; 29463039; 29498767; 29532899; 29626520; 29670668; 29695550; 29763735; 29883760; 29947568; 29970511; 29992758; 30015831; 30117779; 30171660; 30177524; 30221334; 30327948; 30328228; 30379883; 3038863; 30440036; 30458287; 30594980; 30627228; 30633757; 30664222; 30691874; 30715578; 30789935; 30825334; 30886066; 31001893; 31080992; 31115512; 31124635; 31129674; 31215762; 31244308; 31264811; 31311559; 31348577; 31356534; 31366549; 31389576; 31444694; 31525531; 31526198; 31652448; 31653934; 31670855; 31677173; 31903873; 31917802; 31932027; 31977248; 32014911; 32218695; 32317080; 32323782; 32350561; 32417757; 32437034; 32555355; 32556014; 32596320; 32650441; 32702237; 32703314; 32769324; 33002044; 33055012; 33058879; 33090337; 33157237; 33170424; 33309320; 33331536; 33391541; 33396463; 33449301; 33487115; 33684534; 33737203; 33761760; 33885811; 33888009; 33902302; 34171070; 34233423; 34280010; 34369270; 34410940; 34445715; 34459757; 34477058; 34561981; 34969762; 6270089; 6322761; 6694361; 7523391; 7547873; 7641497; 7669817; 7780967; 7890717; 7896811; 7981201; 8015608; 8194591; 8216228; 8223643; 8305481; 8380588; 8405676; 8463259; 8576151; 8603731; 8621622; 8668165; 8817670; 8920930; 8999957; 9065415; 9092507; 9115292; 9335112; 9346290; 9578462; 9651395; 9922210;
Motif MOTIF 90..97; /note="Cysteine switch"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:2153297"
Gene Encoded By
Mass 54,007
Kinetics
Metal Binding METAL 92; /note="Zinc 2; in inhibited form"; /evidence="ECO:0000269|PubMed:15611040, ECO:0007744|PDB:1SU3"; METAL 124; /note="Calcium 1"; /evidence="ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:966C"; METAL 158; /note="Calcium 2"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 168; /note="Zinc 1"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 170; /note="Zinc 1"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 175; /note="Calcium 3"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 176; /note="Calcium 3; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 178; /note="Calcium 3; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 180; /note="Calcium 3; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 183; /note="Zinc 1"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 190; /note="Calcium 2; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 192; /note="Calcium 2; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 194; /note="Calcium 2"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 196; /note="Zinc 1"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 198; /note="Calcium 3"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 199; /note="Calcium 1"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 201; /note="Calcium 3"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C"; METAL 218; /note="Zinc 2; catalytic"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 222; /note="Zinc 2; catalytic"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 228; /note="Zinc 2; catalytic"; /evidence="ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C"; METAL 285; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:4AUO"; METAL 329; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:4AUO"; METAL 378; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:4AUO"; METAL 427; /note="Calcium 4; via carbonyl oxygen"; /evidence="ECO:0000269|PubMed:15611040, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:4AUO"
Rhea ID
Cross Reference Brenda 3.4.24.7;