| IED ID | IndEnz0002006323 |
| Enzyme Type ID | protease006323 |
| Protein Name |
Mitochondrial-processing peptidase subunit alpha Alpha-MPP Inactive zinc metalloprotease alpha |
| Gene Name | PMPCA |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MAAMVLAATRLLRGSGSWGRSRPRFGDPAYRRFSSGGAYPNIPLSSPLPGVPKPVFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSSTERFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVGLLADVVLHPRLTDEEIEMARMAVQFELEDLNMRPDPEPLLTEMVHEAAYRENTVGLHRFCPAENVGKMDRDVLHAYLRNYYTPDRMVLAGVGVEHAQLVECARKYLLGTCPAWGTGAAVHVDRSVAQYTGGIVKLERDMSNVSLGPTPFPELTHIMIGLESCSFLEGDFIPFAVLNMMMGGGGSFSAGGPGKGMFTRLYLNVLNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIVTREFVLMAGTVDVVELERAKTQLTSMLMMNLEARPVIFEDVGRQVLATRSRKLPHELCALIRDVKPEDIKRVASKMLRGKPAVAALGDLSELPAYEHVQAALASRDGRLPRVYRLFR |
| Enzyme Length | 525 |
| Uniprot Accession Number | Q0P5M8 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. {ECO:0000250|UniProtKB:Q10713}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Modified residue (2); Transit peptide (1) |
| Keywords | Acetylation;Membrane;Mitochondrion;Mitochondrion inner membrane;Reference proteome;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P20069}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q10713}. |
| Modified Residue | MOD_RES 64; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:Q9DC61; MOD_RES 299; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:Q10713 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 58,135 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |