| IED ID | IndEnz0002006393 |
| Enzyme Type ID | protease006393 |
| Protein Name |
Kyphoscoliosis peptidase EC 3.4.-.- |
| Gene Name | Ky |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MELKKDSNAVAIDMLLIVHSEKRRAAQATHLDPQANPGALLQNRGGFQGVRNGIRKWQELEENSFQGNLPEKQCLQQPQVITSYDNQGTQLTVEIHPQDAMPQLLKKFSLAKRLQGDKNGNMRPRQPGGKDAHAYPWDRSSLKSMPLDLRLFEKLDASASQVTVKSGLNELVSDLLQEAHSDLERVRAIWIWICHHIEYDVEAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRVAGVQCVTVPGYSKGFGYQTGQSFSGEFDHAWNAVYLEGRWHLVDSTWGSGLVDTTTSKFTFLYNEFYFLTHPALFIEDHFPDNKNWQLLKPPQSLRQFENSMYHKSEFYNKGMLSAHPETSMIRTVNGKATITIESRAPTLFMFMLNGKQEHGLLSLRKNGMKLEVYPPTMGTHKLQIFAKGNSEIYSSVLEYTLKCNYVDFSVQLPSELHQPVGPSWFSEQMGITKPSHSDPIIHTSDGRCAISFSVEEGVSVLASLHGDDGPITEETQRRYIFQLNRGKRTELKVQLPHAGKFALKIFVKKRQEQGNFIFVFNYLLCCANTKVNWPMFPESFGNWGQDNELLEPLSGVLPANRNVAFKLKLHGIAKALVKGQDTWPLTLNPEGYWEGSCNTAGCQEVYVMVLENANHNFYSYILKYKVNDQ |
| Enzyme Length | 661 |
| Uniprot Accession Number | Q8C8H8 |
| Absorption | |
| Active Site | ACT_SITE 225; /evidence=ECO:0000250; ACT_SITE 267; /evidence=ECO:0000250; ACT_SITE 282; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC. {ECO:0000269|PubMed:11136708, ECO:0000269|PubMed:15385448}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1); Region (1); Sequence conflict (3) |
| Keywords | Alternative splicing;Cytoplasm;Cytoskeleton;Hydrolase;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12204272; 12466851; 1372391; 15036332; 16806927; 17574766; 22820870; 25860951; 29914939; 4123573; 6527158; 7774920; 7864091; 8944783; 9878244; |
| Motif | |
| Gene Encoded By | |
| Mass | 75,090 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |