| IED ID |
IndEnz0002006395 |
| Enzyme Type ID |
protease006395 |
| Protein Name |
Hirudin-P6
|
| Gene Name |
|
| Organism |
Poecilobdella manillensis (Mexican medical leech) (Hirudinaria manillensis) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Spiralia
Lophotrochozoa
Annelida
Clitellata
Hirudinea (leeches)
Hirudinida
Hirudiniformes
Hirudinidae
Poecilobdella
Poecilobdella manillensis (Mexican medical leech) (Hirudinaria manillensis)
|
| Enzyme Sequence |
MRYTACTESGQNQCICEGNDVCGQGRNCQFDSSGKKCVEGEGTRKPQNEGQHDFDPIPEEYLS |
| Enzyme Length |
63 |
| Uniprot Accession Number |
P28512 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (1); Disulfide bond (3); Glycosylation (1); Modified residue (1); Region (3) |
| Keywords |
Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Secreted;Serine protease inhibitor;Sulfation |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
MOD_RES 61; /note=Sulfotyrosine; /evidence=ECO:0000269|PubMed:1540584 |
| Post Translational Modification |
PTM: O-linked glycan consists of Fuc-Gal-GalNAc trisaccharide. |
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
6,977 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|