| IED ID | IndEnz0002006413 |
| Enzyme Type ID | protease006413 |
| Protein Name |
Aspartic protease 10 EC 3.4.23.- Heme transporter hrg-7 Heme-responsive gene 7 protein |
| Gene Name | hrg-7 asp-10 C15C8.3 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKTFIALLALLTVVSAEVHQFNIGYRPNMRQRMNAKGKLAEYEKERNELLSKKSLQLASSSSPVIDYEDMAYMVQISLGSPAQNFVLFIDSGSSNLWVPDITCAGGKDATCGSYCKSTPYDACLTFCQEECCTKTVEGVKVLSTTDACQSKHRFNSSLSSSYVTNGQKFDMTYNTGEVKGFFGVDTFCFTNTSVCATGQVFGQATTIGEAFAKQPEDGIIGLGWPALAVNQQTPPLFNLMNQGKLDQPYFVVYLANIGPTSQINGGAFTVGGLDTTHCSSNVDWVPLSTQTFWQFKLGGVSSGSYSQAPNSGWQAAADTAASFIGAPKSVVTSLAKAVGATYVPLTGAFFMDCDAVVPDIVFTINGKTYNMPSTSFVVSAGPGPCMFAFYELTAGGFYPAWMLGPPFMRAYCHVHDMKSGRLGLAKVL |
| Enzyme Length | 428 |
| Uniprot Accession Number | Q18020 |
| Absorption | |
| Active Site | ACT_SITE 90; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103; ACT_SITE 318; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Aspartic protease which plays a role in heme homeostasis and mediates inter-organ signaling between the intestine and extra-intestinal tissues when cellular heme levels are low. {ECO:0000269|PubMed:28581477}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (1); Chain (1); Disulfide bond (1); Domain (1); Glycosylation (2); Propeptide (1); Signal peptide (1) |
| Keywords | Alternative splicing;Aspartyl protease;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | INDUCTION: By heme deficiency. {ECO:0000269|PubMed:28581477}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28581477}. |
| Modified Residue | |
| Post Translational Modification | PTM: Proteolytically cleaved. {ECO:0000305|PubMed:28581477}. |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16672054; 21367940; 22560298; 23800452; 25487147; 29348603; |
| Motif | |
| Gene Encoded By | |
| Mass | 45,993 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |