| IED ID | IndEnz0002006452 |
| Enzyme Type ID | protease006452 |
| Protein Name |
Metacaspase-1A EC 3.4.22.- |
| Gene Name | casA AO090001000470 |
| Organism | Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Circumdati Aspergillus oryzae (Yellow koji mold) Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
| Enzyme Sequence | MHHQQSSYGGGYPGQAYRQQQPNNAYGYGQPSPQPYGSHHNGYNSPQQNYGPPSGGHMYQQQSAYQNSYNQGGHGIPARPPDQPVSFGQGAPQEYAYRYSACTGTRKALLIGINYFNQKGQLRGCINDVKNMSTYLHENFGYPRENMVLLTDDQQNPKSQPTKANILRAMHWLVKDAKPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRQAGHIVDDEMHRIMVNPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMGSMVSTAVGFFKKATKGDEVYERNKQTKTSGADVIMWSGSKDDQTSQDAQIQGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELSTKYTQKPQLSCSHPLGDLIDVPVLGSGFIWFWVLSIFQCQATK |
| Enzyme Length | 419 |
| Uniprot Accession Number | Q2UN81 |
| Absorption | |
| Active Site | ACT_SITE 190; /evidence=ECO:0000250; ACT_SITE 246; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (1); Propeptide (1); Region (1) |
| Keywords | Apoptosis;Hydrolase;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 46,374 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |