| IED ID | IndEnz0002006480 |
| Enzyme Type ID | protease006480 |
| Protein Name |
Mitochondrial intermediate peptidase 1 MIP 1 EC 3.4.24.59 Octapeptidyl aminopeptidase 1 |
| Gene Name | OCT1 CNBC3550 |
| Organism | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. neoformans Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Enzyme Sequence | MLRLPRITRRALSSGALAPHFDRPLPPPPPAPPAPLCALPPLTAPDALAPLTRRTVRHADALVARIAAAPAHPDPAELRRVVKNLDRLSDVLCGVIDMCELVRNVHPDPHWVAAAEKTYETLCSFMNQLNTSTGLYDALVATVSHTFPGNPLSPAELRVAQTFLSDFERSGIQLPPGVRAKFVRHSDNILSLGRTFLSFAAAGPSADTPIEIPEPEVLLAGLSSKFVASLPRKKRKGPALLAPGSWEAQMIGRYADNEEARRLVYIGSMREDKDRVYVLETMLKERAELAHVLGKETWADVALSDKMAKTPQNVLQFLTSLATHHRPSAAADVAALQRLKALSTVSRTSSQLPTVHAWDRDHYAEQYAASLLPNGSLPSITPYFSVGTAMSGLSHMLSRLYGISFKPVSVAHGEVWHPSVRRLDVMDEHGKRIGVIYCDLFSRPGKPSAGAAHYTVRCSRRVDDDPSEGDGLPPGWDQHLGKGMEVQGEALHGKEGKYQLPIVVLTTDFGTVEESGPALLGWNDLETLFHEMGHAIHSMIGQTEFHNVSGTRCATDFVELPSILMEHFISSPAVLSTFATHYTTNEPLPIPLIQAHLQLDQSLKALETHSQILMALLDQKYHSIKHGEQLDSTRVWNELQSQVGVIPPVRGTAWQTQFGHLYGYGATYYSYLFDRAIAGKIWSSLFARGRTGPAAANHDPAAAEDILSREGGEAFKEKVLKWGGGRDPWEMVGDVIGGAEGEQVAKGDEKAMELVGRWMIK |
| Enzyme Length | 761 |
| Uniprot Accession Number | P0CQ19 |
| Absorption | |
| Active Site | ACT_SITE 531; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.; EC=3.4.24.59; |
| DNA Binding | |
| EC Number | 3.4.24.59 |
| Enzyme Function | FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Metal binding (3); Transit peptide (1) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Mitochondrion;Protease;Transit peptide;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 83,271 |
| Kinetics | |
| Metal Binding | METAL 530; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 534; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 537; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |