| IED ID | IndEnz0002006503 |
| Enzyme Type ID | protease006503 |
| Protein Name |
Inter-alpha-trypsin inhibitor heavy chain H4 ITI heavy chain H4 ITI-HC4 Inter-alpha-inhibitor heavy chain 4 |
| Gene Name | ITIH4 |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MKTPAPGRIHSIVLVLLSLAVLQTSKAQKVQNDIDIYSLTVDSKVSSRFAHTVITSRVVNKADAVREATFQMELPKKAFITNFSMVIDGVTYPGNIKEKAAAQEQYSAAVARGESAGLVRATGRKTEQFQVSVSVAPAAKVTFELVYEELLARHLGAYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNKLAEALTTSQNKTKAHVRFKPTLSQQQKYPEKQDTVIDGSFIVRYDVDRPLSGGSIQIENGYFVHYFAPDSLSTIPKNVIFVIDKSGSMMGRKIKQTREALIKILDDLSPHDQFDLISFSSEATTWKPLLVPASTENVNEAKSYATGIQAQGGTNINDAMLMAVQLLEKANQEELLPEGSITLIILLTDGDPTVGETNPLNIQKNVRKAINGQHSLFCLGFGFDVSYAFLEKMALENGGLARRIYEDSDSALQLQDFYQEVANPLMTSVAFEYPSNAVESVTQDTFRVFFKGSELVVAGKLREQSPDVLLAQIRGQLHRENITYMMMSHVAEQEEMFRSPKYIFHSFIERLWAYLTIQQLLEQMVSALDAEKQALEARALSLSLSYSFVTPLTSMVITKPEGQEQSQVAEKPVEDESRGSRVYLGPMRFGHSVGDRTSRKPGGGLKLLNGTPLFGPPGPPAAASPFHRMTSRLVLPELMSPLAPASAPSPTSGPGGASHDTDFRIKGTTPTALPFAPVQAPSVILPLPGQSVDRLCVDLRRPQELVNLLSDPDQGVEVTGHFETAKARFSWIEVTFENPQVQIHASPEHVVMTRNRRNSAYKWKETLYSVMPGLKVTMDKEGLLLLSRPDRVTIGLLFWDGPGKGLRLLLQNTDRFSSHVSGTLGQFYQDVLWGPLDTADDSKRTLKVQGRDYSATRELKLDYQESPPGKEISCWSVEL |
| Enzyme Length | 916 |
| Uniprot Accession Number | Q3T052 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269|PubMed:15213118}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Domain (2); Glycosylation (7); Region (2); Sequence conflict (3); Signal peptide (1) |
| Keywords | Acute phase;Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | INDUCTION: Levels of ITIH4 in serum increase 3- to 12-fold on inoculation with various bacteria which induce mastitis. Peak levels are reached around 42h-72 h after infection. {ECO:0000269|PubMed:15213118}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15213118}. |
| Modified Residue | |
| Post Translational Modification | PTM: Appears to be both N- and O-glycosylated. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 101,513 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |