| IED ID | IndEnz0002006510 |
| Enzyme Type ID | protease006510 |
| Protein Name |
Nucleoside-diphosphatase mig-23 NDPase EC 3.6.1.6 Abnormal cell migration protein 23 |
| Gene Name | mig-23 R07E4.4 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MRVSLRFTILAVSAMIFFPVIVFIYVVEAHTSPKVIADDQERSYGVICDAGSTGTRLFVYNWISTSDSELIQIEPVIYDNKPVMKKISPGLSTFGTKPAQAAEYLRPLMELAERHIPEEKRPYTPVFIFATAGMRLIPDEQKEAVLKNLRNKLPKITSMQVLKEHIRIIEGKWEGIYSWIAVNYALGKFNKTATLDFPGTSPAHARQKTVGMIDMGGASAQIAFELPDTDSFSSINVENINLGCREDDSLFKYKLFVTTFLGYGVNEGIRKYEHMLLSKLKDQNGTVIQDDCMPLNLHKTVTLENGENFVRRGTGNWNTCSNEVKKLLNPESSSEVCKAEAAKCYFGAVPAPSIPLSNIEMYGFSEYWYSTHDVLGLGGQYDAENIAKKTQQYCSKRWSTIQAESKKQLYPRADEERLRTQCFKSAWITSVLHDGFSVDKTHNKFQSVSTIAGQEVQWALGAMIYHMRFFPLRDSSRNLIVKETHSSSESLWAPLFFLSAVFCLFVLVCAKEQSVLCFDDKRRSSFGMSRSQYSYKMLKENRTSSSFLENFA |
| Enzyme Length | 552 |
| Uniprot Accession Number | Q21815 |
| Absorption | |
| Active Site | ACT_SITE 174; /note=Proton acceptor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6; |
| DNA Binding | |
| EC Number | 3.6.1.6 |
| Enzyme Function | FUNCTION: Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig-17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis. {ECO:0000269|PubMed:14688791}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (2); Mutagenesis (2); Topological domain (3); Transmembrane (2) |
| Keywords | Developmental protein;Differentiation;Glycoprotein;Golgi apparatus;Gonadal differentiation;Hydrolase;Membrane;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | INDUCTION: In contrast to uda-1, expression is not induced by stress. |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:14688791, ECO:0000269|PubMed:16354716}; Multi-pass membrane protein {ECO:0000269|PubMed:14688791, ECO:0000269|PubMed:16354716}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15338614; 17850180; 21177967; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 62,511 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:36799 |
| Cross Reference Brenda |