| IED ID | IndEnz0002006512 |
| Enzyme Type ID | protease006512 |
| Protein Name |
Integrin alpha-2 CD49 antigen-like family member B Collagen receptor Platelet membrane glycoprotein Ia GPIa VLA-2 subunit alpha CD antigen CD49b |
| Gene Name | ITGA2 CD49B |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSEQFGYAVQQFINPKGNWLLVGSPWSGFPENRMGDVYKCPVDLSTATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWAQQCGNQYYTTGVCSDISPDFQLSASFSPATQPCPSLIDVVVVCDESNSIYPWDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQILQDRNHSSYLGYSVAAISTGESTHFVAGAPRANYTGQIVLYSVNENGNITVIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFGQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILKLCFSAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVNQAQSCPEHIIYIQEPSDVVNSLDLRVDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASLSFQALSESQEENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHSFEDVGPKFIFSLKVTTGSVPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENFRHTKELNCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPEIYVIEDNTVTIPLMIMKPDEKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKRKYEKMTKNPDEIDETTELSS |
| Enzyme Length | 1181 |
| Uniprot Accession Number | P17301 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 499..507; /evidence=ECO:0000255; CA_BIND 563..571; /evidence=ECO:0000255; CA_BIND 627..635; /evidence=ECO:0000255 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. {ECO:0000269|PubMed:12941907}.; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. {ECO:0000269|PubMed:8411387}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (5); Calcium binding (3); Chain (1); Disulfide bond (6); Domain (1); Glycosylation (10); Helix (11); Motif (1); Mutagenesis (7); Natural variant (5); Region (1); Repeat (7); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (1) |
| Keywords | 3D-structure;Calcium;Cell adhesion;Direct protein sequencing;Disulfide bond;Glycoprotein;Host cell receptor for virus entry;Host-virus interaction;Integrin;Magnesium;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | P05556; P35968; Q9H0F6; P84092; P35282; P04512 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..29; /evidence=ECO:0000269|PubMed:2545729 |
| Structure 3D | X-ray crystallography (16) |
| Cross Reference PDB | 1AOX; 1DZI; 1V7P; 4BJ3; 5HJ2; 5THP; 6ND8; 6ND9; 6NDA; 6NDB; 6NDC; 6NDD; 6NDE; 6NDF; 6NDG; 6NDH; |
| Mapped Pubmed ID | 10194421; 10366422; 10521801; 10688808; 10778855; 11015342; 11238113; 11246537; 11323022; 11395045; 11472360; 11518510; 11568114; 11572855; 11698306; 11728949; 11775028; 11776052; 11809527; 11812069; 11835340; 11877061; 11958806; 11978651; 12038776; 12070018; 12071877; 12073410; 12082590; 12082592; 12181354; 12208476; 12372459; 12392763; 12412731; 12423238; 12482840; 12486862; 12499711; 12529399; 12540964; 12544734; 12615788; 12617725; 12657625; 12681287; 12690916; 12717361; 12721290; 12724616; 12788934; 12791669; 12871362; 12871600; 12915563; 12928694; 13679375; 14556196; 14563588; 14563646; 14580195; 14671618; 14679206; 14681217; 14687991; 14701832; 14715956; 14746139; 15104219; 15132990; 15174051; 15205592; 15227729; 15240572; 15276841; 15292257; 15304053; 15350465; 15355503; 15355504; 15383545; 15479743; 15514009; 15522237; 15546585; 15630502; 15647274; 15699160; 15730528; 15777792; 15847651; 15892865; 15947241; 15978109; 15978110; 16043429; 16055706; 16113793; 16140647; 16157382; 16214444; 16304451; 16317580; 16380674; 16390868; 16413178; 16421008; 16513317; 16573563; 16582881; 16622460; 16697311; 16732726; 16754661; 16782899; 16793669; 16820192; 16828471; 16875034; 16882656; 16905953; 16908762; 16945929; 16972245; 1697296; 17003923; 17023078; 17036337; 17070428; 17127487; 17157856; 17160992; 17164499; 17170699; 17184645; 17196570; 17264949; 17312461; 17314405; 17331499; 17346829; 17408410; 17485091; 17495265; 17498594; 17534386; 17538005; 17598123; 17630485; 17638891; 17669516; 17728329; 17890945; 18026855; 18057877; 18231737; 18362184; 18413316; 18448666; 18491034; 18502778; 18513389; 18554474; 18587047; 18608122; 18613064; 18638089; 18787945; 18806884; 18820259; 18826391; 18830231; 18836731; 18936436; 18974842; 18983487; 18990704; 19008959; 19082798; 19110485; 19131662; 19132198; 19202951; 19204726; 19235843; 19336370; 19350519; 19367725; 19388931; 19395705; 19411307; 19420105; 19422573; 19451223; 19463016; 19479237; 19500323; 19530321; 19549780; 19559392; 19570064; 19578796; 19587357; 19622836; 19635510; 19700757; 19702628; 19724904; 19729601; 19740098; 19778317; 19789264; 19789387; 19827952; 19913121; 19948007; 19995941; 20063990; 20076847; 20149160; 20178602; 20201926; 20204402; 20336352; 20351310; 20436081; 20453000; 20485444; 20532885; 20536507; 20598296; 20628086; 20667040; 20691446; 20705068; 20802519; 20806289; 20939067; 21034162; 21126803; 21134100; 21135504; 21193198; 21262375; 21474814; 21508388; 21558389; 21596751; 21632096; 21647271; 21652699; 21658756; 21672359; 21734795; 21743959; 21765051; 21787362; 21796158; 21850018; 21947080; 22015659; 22049795; 22133774; 22160595; 22298882; 22304920; 22354032; 22590584; 22948415; 23116973; 23132859; 23161041; 23204528; 23242739; 23249684; 23284937; 23418787; 23469002; 23638215; 23922814; 23951036; 24244022; 24289209; 24397542; 24466284; 24501414; 24581850; 24595049; 24616281; 24837519; 24850451; 24958723; 24959655; 24979111; 25046655; 25137483; 25200184; 25203434; 25549357; 25643034; 25658015; 25966234; 26051322; 26134877; 26152212; 26258411; 26304618; 26408663; 26496610; 26514956; 26556301; 26700675; 26758421; 26779610; 26927558; 27009236; 27011248; 27019315; 27221710; 27405521; 27881421; 28004990; 28119367; 28358707; 28388872; 28669815; 28704364; 28948649; 29121049; 29208186; 29236307; 29440721; 29461866; 29540503; 29761640; 30132837; 30515639; 30545930; 30798327; 31102273; 31184100; 31641961; 31818309; 32202508; 32317629; 32433445; 32437034; 33276802; 33297767; 33557870; 34171483; 34204767; 34599900; 34944014; 7559467; 7693733; 8118028; 8344274; 8798654; 9058714; 9361014; 9367446; 9645947; 9746778; 9949188; 9950439; |
| Motif | MOTIF 1157..1161; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 129,296 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |