| IED ID | IndEnz0002006513 |
| Enzyme Type ID | protease006513 |
| Protein Name |
Integrin alpha-2 CD49 antigen-like family member B Collagen receptor Platelet membrane glycoprotein Ia GPIa VLA-2 subunit alpha CD antigen CD49b |
| Gene Name | Itga2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MGPGQAGGALLLRLLMLVQGILNCLAYNVGLPGAKIFSGPSSEQFGYSVQQLTNPQGNWLLVGSPWSGFPENRMGDVYKCPVDLPTATCEKLNLQNSASISNVTEIKTNMSLGLTLTRNPGTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQFLTSFSPAVQACPSLVDVVVVCDESNSIYPWEAVKNFLVKFVTGLDIGPKKTQVALIQYANEPRIIFNLNDFETKEDMVQATSETRQHGGDLTNTFRAIEFARDYAYSQTSGGRPGATKVMVVVTDGESHDGSKLKTVIQQCNDDEILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMAQVGFSADYAPQNDILMLGAVGAFDWSGTLVQETSHKPVIFPKQAFDQVLQDRNHSSFLGYSVAAISTEDGVHFVAGAPRANYTGQIVLYSVNKQGNVTVIQSHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPTYMNDLKKEEGKVYLFTITKGILNQHQFLEGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGSNGAFRRHLQFFGRSLDGYGDLNGDSITDVSIGALGQVIQLWSQSIADVAIEALFTPDKITLLNKDAKITLKLCFRAEFRPAGQNNQVAILFNMTLDADGHSSRVTSRGVFRENSERFLQKNMVVNEVQKCSEHHISIQKPSDVVNPLDLRVDISLENPGTSPALEAYSETVKVFSIPFYKECGSDGICISDLILDVQQLPAIQTQSFIVSNQNKRLTFSVILKNRGESAYNTVVLAEFSENLFFASFSMPVDGTEVTCEVGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQNQAAINFQAFSESQETNKADNSVSLTIPLLYDAELHLTRSTNINFYEISSDENAPSVIKSVEDIGPKFIFSLKVTAGSAPVSMALVTIHIPQYTKEKNPLLYLTGIQTDQAGDISCTAEINPLKLPHTAPSVSFKNENFRHTKELDCRTTSCSNITCWLKDLHMKAEYFINVTTRVWNRTFAASTFQTVQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGILLLLAMTAGLWKLGFFKRQYKKMGQNPDEMDETTELNS |
| Enzyme Length | 1178 |
| Uniprot Accession Number | Q62469 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 496..504; /evidence=ECO:0000255; CA_BIND 560..568; /evidence=ECO:0000255; CA_BIND 624..632; /evidence=ECO:0000255 |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Calcium binding (3); Chain (1); Disulfide bond (6); Domain (1); Glycosylation (9); Motif (2); Repeat (7); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Calcium;Cell adhesion;Disulfide bond;Glycoprotein;Integrin;Magnesium;Membrane;Metal-binding;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..26; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10090148; 10206722; 10501972; 10706142; 10742111; 11431366; 11438667; 11767049; 11788609; 12107118; 12466851; 12721290; 12843252; 12893751; 12904471; 12960301; 1431091; 14645004; 14707119; 14739220; 14994542; 15132990; 15183724; 15227729; 15368439; 15370361; 15886326; 16054021; 16141072; 16166590; 16373693; 16455949; 16618804; 16636073; 16818752; 16882656; 16919269; 16973387; 16977325; 17032352; 17068473; 17638891; 18000613; 18042800; 18086863; 18198349; 18436621; 18498633; 18802064; 18983510; 18990704; 19258597; 19321657; 19411307; 19463772; 19648922; 19668337; 19686679; 19789387; 19815553; 19840869; 20592186; 20651280; 20818394; 21126803; 21134100; 21135504; 21267068; 21270253; 21344393; 21558389; 21897373; 22046385; 22083543; 22103309; 22210772; 22318609; 22687584; 23023225; 23152823; 23165626; 23169063; 23226541; 23359821; 23385480; 23448258; 23624599; 23680479; 23897120; 24194600; 24244022; 24472646; 24480069; 24917135; 24939421; 25194508; 25352128; 25375377; 25391964; 25415203; 2545729; 25634355; 25808553; 25849460; 25859222; 26051322; 26196244; 26556301; 27505889; 27626380; 28251149; 28389839; 28402857; 29333090; 30355617; 30926747; 31398205; 32325713; 32692932; 32998468; 33124775; 7589890; 7691492; 7790117; 8306881; 8521519; 8626034; 8725284; 8828042; 8948576; 9119362; 9339637; 9361014; 9427478; 9858678; |
| Motif | MOTIF 480..482; /note=Cell attachment site; /evidence=ECO:0000255; MOTIF 1154..1158; /note=GFFKR motif |
| Gene Encoded By | |
| Mass | 128,955 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |