IED Industry Enzyme Database

Detail Information for IndEnz0002006514
IED ID IndEnz0002006514
Enzyme Type ID protease006514
Protein Name Integrin beta-3
Platelet membrane glycoprotein IIIa
GPIIIa
CD antigen CD61
Gene Name ITGB3 GP3A
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT
Enzyme Length 788
Uniprot Accession Number P05106
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973, ECO:0000269|PubMed:9195946, ECO:0000303|PubMed:16322781, ECO:0000303|PubMed:17635696}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. {ECO:0000269|PubMed:7519807}.; FUNCTION: (Microbial infection) Acts as a receptor for Hantaan virus. {ECO:0000269|PubMed:9618541}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:15834425}.; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus. {ECO:0000269|PubMed:24478423}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (2); Beta strand (52); Chain (1); Disulfide bond (28); Domain (1); Glycosylation (6); Helix (27); Modified residue (4); Motif (1); Natural variant (39); Region (3); Repeat (4); Sequence conflict (10); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (17)
Keywords 3D-structure;Alternative splicing;Cell adhesion;Cell junction;Cell membrane;Cell projection;Direct protein sequencing;Disease variant;Disulfide bond;Glycoprotein;Host cell receptor for virus entry;Host-virus interaction;Integrin;Membrane;Phosphoprotein;Postsynaptic cell membrane;Receptor;Reference proteome;Repeat;Signal;Synapse;Transmembrane;Transmembrane helix
Interact With P78423; P21333; P08514; P08514-1; P06756; Itself; P14555; P18031; Q9Y490; P05094; F5HB81; Q62101; P05480-2; P26039; P54939; P06935
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single-pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:O54890}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O54890}. Cell junction, synapse {ECO:0000250|UniProtKB:O54890}.
Modified Residue MOD_RES 767; /note="Phosphothreonine"; /evidence="ECO:0000250|UniProtKB:O54890"; MOD_RES 773; /note="Phosphotyrosine"; /evidence="ECO:0000269|PubMed:19141530, ECO:0007744|PubMed:18088087"; MOD_RES 779; /note="Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro"; /evidence="ECO:0000269|PubMed:10896934"; MOD_RES 785; /note="Phosphotyrosine"; /evidence="ECO:0000269|PubMed:8631894"
Post Translational Modification PTM: Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding. {ECO:0000269|PubMed:10896934}.
Signal Peptide SIGNAL 1..26; /evidence=ECO:0000255
Structure 3D NMR spectroscopy (17); Electron microscopy (5); X-ray crystallography (50)
Cross Reference PDB 1JV2; 1KUP; 1KUZ; 1L5G; 1M1X; 1M8O; 1MIZ; 1MK7; 1MK9; 1S4X; 1TYE; 1U8C; 2K9J; 2KNC; 2KV9; 2L1C; 2L91; 2LJD; 2LJE; 2LJF; 2MTP; 2N9Y; 2Q6W; 2RMZ; 2RN0; 2VC2; 2VDK; 2VDL; 2VDM; 2VDN; 2VDO; 2VDP; 2VDQ; 2VDR; 3FCS; 3FCU; 3IJE; 3NID; 3NIF; 3NIG; 3T3M; 3T3P; 3ZDX; 3ZDY; 3ZDZ; 3ZE0; 3ZE1; 3ZE2; 4CAK; 4G1E; 4G1M; 4MMX; 4MMY; 4MMZ; 4O02; 4Z7N; 4Z7O; 4Z7Q; 5HDB; 6AVQ; 6AVR; 6AVU; 6BXB; 6BXF; 6BXJ; 6CKB; 6MK0; 6MSL; 6MSU; 6NAJ; 6V4P; 7KN0;
Mapped Pubmed ID 10025398; 10195947; 10209122; 10409742; 10446041; 10605720; 10640428; 10725339; 10777559; 10891492; 10964917; 11028489; 11053714; 11151063; 11158588; 11235724; 11257275; 11259146; 11279932; 11341749; 11397354; 11447076; 11454259; 11476890; 11533523; 11545752; 11568114; 11583324; 11606749; 11686325; 11704375; 11713259; 11714857; 11728949; 11739968; 11776310; 11812069; 11812775; 11858476; 11858493; 11875117; 11884718; 11891802; 11934894; 11959660; 11962738; 11970960; 11983888; 11994301; 12005431; 12031826; 12049640; 12068308; 12071877; 12073410; 12082590; 12082592; 12140290; 12152649; 12152651; 12161360; 12168086; 12198771; 12200372; 12209993; 12210725; 12218055; 12230976; 12237112; 12237321; 12297512; 12358597; 12362250; 12364323; 12370491; 12372469; 12372811; 12393510; 12399420; 12415008; 12427871; 12460991; 12473660; 12482840; 12486108; 12499711; 12511588; 12514663; 12518110; 12535520; 12553378; 12578602; 12585966; 12586134; 12606711; 12609844; 12637342; 12639965; 12640026; 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Motif MOTIF 777..783; /note="LIR"; /evidence="ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498"
Gene Encoded By
Mass 87,058
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda