| IED ID | IndEnz0002006523 |
| Enzyme Type ID | protease006523 |
| Protein Name |
Matrix metalloproteinase-21 MMP-21 EC 3.4.24.- |
| Gene Name | MMP21 |
| Organism | Cynops pyrrhogaster (Japanese fire-bellied newt) (Molge pyrrhogaster) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amphibia Batrachia Caudata Salamandroidea Salamandridae (newts) Pleurodelinae Cynops (firebelly newts) Cynops pyrrhogaster (Japanese fire-bellied newt) (Molge pyrrhogaster) |
| Enzyme Sequence | MPTAPALGALLLLLGALTPGHQEKLFHSRDHSDLQPSPQHQAELVTDLQSAQQFLSKYGWTEPVKWEGTSSKNAAELPRYGDADLMQEGASISRYGQEFPLEPTQAPAFVEALRKFQTLNGLPATGKLDDSTIAAMNKPRCGVPDNQIGKESAIVKSNSNNVTEKASGKSLNTTTNQNPENGTSTSKIRKKRFLQMLAAPVRYKDQANQGSTVRGAFSKKLLKWRLIGEGYSSQLSIDEQRYVFKTAFRMWSEVMPLDFEEDLTSPMSLIDVKLGFGRGRHLGCTRSFDGSGQEFAHAWFLGDIHFDDDEHFTAPSSDSGISLLKVAVHEIGHVLGLSHIYQTGSIMQPNYIPQEAGFELDWTDRKAIQMLYGTCEGSFDAVFDWIWKERNQYGELVLRYNTYFFRNAWYWLYENRKNRTRYGDPVTVSLGWHGIPAEGIDAFVHVWTWTEDATYFFKGTQYWRYDSENDQAYIKDAQGNQYPRLISEGFPKIPSPINTAFFDRRDQFIYFFKDAHVYAFDVKRNMVANHYPKRIIDVFPAVVRNNHPFGNIDAAYYAYTHNSIFLFKGKEYWKVVSDKDRQQNPKLPRNGLFLKKNISEQWTDICNVHSSMLKMR |
| Enzyme Length | 616 |
| Uniprot Accession Number | Q90YC2 |
| Absorption | |
| Active Site | ACT_SITE 330; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: May play a role in gastrulation-related cell movement (PubMed:11606053). Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (By similarity). {ECO:0000250|UniProtKB:O93470, ECO:0000250|UniProtKB:Q8N119, ECO:0000269|PubMed:11606053}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (1); Glycosylation (5); Metal binding (4); Motif (1); Propeptide (1); Region (1); Repeat (4); Signal peptide (1) |
| Keywords | Calcium;Cleavage on pair of basic residues;Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Repeat;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 139..146; /note=Cysteine switch; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 70,428 |
| Kinetics | |
| Metal Binding | METAL 141; /note=Zinc; in inhibited form; /evidence=ECO:0000250; METAL 329; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 333; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 339; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |