| IED ID | IndEnz0002006525 |
| Enzyme Type ID | protease006525 |
| Protein Name |
Matrix metalloproteinase-23 MMP-23 EC 3.4.24.- Matrix metallopeptidase 23B Cleaved into: Matrix metalloproteinase-23, soluble form |
| Gene Name | MMP23 MMP23B |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MGRGACVPSAASGAGDRARQLGAVLGALCLFPALVLLAWPGTPANGAGARVAQGDAAPQTSGVLASGSLGPPHPPVPRRRRYTLTPARLRWEHFNLTYKILSFPRNLLSPSETRRGLAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPVNHTDCLVSPLHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGRTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDRLFVCASWARRGFCDTRRRLMKRLCPSSCDFCYEFPFPTVAATPPPPRTKTKLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSYPGYLALGEAHLSIIANAINEGTYTCVVRRRQRVLSTYSWRIRVRS |
| Enzyme Length | 393 |
| Uniprot Accession Number | Q2TBM7 |
| Absorption | |
| Active Site | ACT_SITE 215; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (2); Disulfide bond (4); Domain (2); Glycosylation (4); Metal binding (3); Propeptide (1); Region (1); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cleavage on pair of basic residues;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Immunoglobulin domain;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000250}.; PTM: Proteolytic cleavage might yield an active form. {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 43,964 |
| Kinetics | |
| Metal Binding | METAL 214; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 218; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 224; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |