| IED ID |
IndEnz0002006544 |
| Enzyme Type ID |
protease006544 |
| Protein Name |
Protein K7
|
| Gene Name |
VACWR039 K7R |
| Organism |
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) |
| Taxonomic Lineage |
Viruses
Varidnaviria
Bamfordvirae
Nucleocytoviricota
Pokkesviricetes
Chitovirales
Poxviridae
Chordopoxvirinae
Orthopoxvirus
Vaccinia virus
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
|
| Enzyme Sequence |
MATKLDYEDAVFYFVDDDKICSRDSIIDLIDEYITWRNHVIVFNKDITSCGRLYKELMKFDDVAIRYYGIDKINEIVEAMSEGDHYINFTKVHDQESLFATIGICAKITEHWGYKKISESRFQSLGNITDLMTDDNINILILFLEKKLN |
| Enzyme Length |
149 |
| Uniprot Accession Number |
P68466 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (1); Chain (1); Helix (11); Turn (1) |
| Keywords |
3D-structure;Host-virus interaction;Inhibition of host NF-kappa-B by virus;Inhibition of host RLR pathway by virus;Inhibition of host innate immune response by virus;Reference proteome;Viral immunoevasion |
| Interact With |
O00571 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
NMR spectroscopy (1); X-ray crystallography (1) |
| Cross Reference PDB |
2K36;
3JRV;
|
| Mapped Pubmed ID |
18845156;
22810585;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
17,468 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|