Detail Information for IndEnz0002006555
IED ID IndEnz0002006555
Enzyme Type ID protease006555
Protein Name Pheromone-processing carboxypeptidase KEX1
EC 3.4.16.6
Carboxypeptidase D
Gene Name KEX1 Lema_P047160
Organism Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta dothideomyceta Dothideomycetes Pleosporomycetidae Pleosporales Pleosporineae Leptosphaeriaceae Leptosphaeria Leptosphaeria maculans species complex Leptosphaeria maculans (Blackleg fungus) (Phoma lingam) Leptosphaeria maculans 'brassicae' group Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam)
Enzyme Sequence MASTYSTPRWRTALLGGFLTTLPWLSSGMAGKTQADYFIKSLPGAPEPLLKMHAGHIEVDAEHNGNLFFWHYENRHIADRQRTVLWLNGGPGCSSMDGALMEVGPYRVQADGNLHYNNGSWDEFANLLFVDQPVGTGFSYVNTDSYLTELDQMANHMVIFLEKWFGLFPEYEHDDLYIAGESYAGQHIPYIARAIVKRNKEQGKTPWALKGLLIGNGWISPVDQYLSYIPYAYQNGLMKADSDMAKRVENQQRICIKKLEDGGMDAVDTNDCEQIMVNILEETKDRKADRMNQCVNMYDIRLRDDASCGMNWPPDLASVTPYLRRPDVIQALHINPDKKTGWQECNGAVSGHFRAKKSEPSVRFLPELIPEVPTLLFSGDKDFICNHIGTEEMIKNMQWSGGKGFEVTPGVWAPKQDWTFEGEAAGSWQEARNLTYVVFYNSSHMVPFDYPRRTRDMLDRFMGVDIEQIGGVPSDSRIDGEKGPLTSVGDHPNSTRAEEDKATDVKQAEWKAYYRSGQVALVVVVIVAALWGIFLWRSRRRHTKTAYQGDDGDEGRESLLTGMGLDNFRRKERRSDLEAADFDERELDDLDGASKKPGNGYASLGSEKERQSHNDSTFSLGGDSDDEAGSSDGPKRKGGSS
Enzyme Length 641
Uniprot Accession Number E5R540
Absorption
Active Site ACT_SITE 182; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 382; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 444; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Preferential release of a C-terminal arginine or lysine residue.; EC=3.4.16.6;
DNA Binding
EC Number 3.4.16.6
Enzyme Function FUNCTION: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Glycosylation (4); Region (2); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords Apoptosis;Carboxypeptidase;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..35; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 72,004
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda