IED ID | IndEnz0002006555 |
Enzyme Type ID | protease006555 |
Protein Name |
Pheromone-processing carboxypeptidase KEX1 EC 3.4.16.6 Carboxypeptidase D |
Gene Name | KEX1 Lema_P047160 |
Organism | Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta dothideomyceta Dothideomycetes Pleosporomycetidae Pleosporales Pleosporineae Leptosphaeriaceae Leptosphaeria Leptosphaeria maculans species complex Leptosphaeria maculans (Blackleg fungus) (Phoma lingam) Leptosphaeria maculans 'brassicae' group Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam) |
Enzyme Sequence | MASTYSTPRWRTALLGGFLTTLPWLSSGMAGKTQADYFIKSLPGAPEPLLKMHAGHIEVDAEHNGNLFFWHYENRHIADRQRTVLWLNGGPGCSSMDGALMEVGPYRVQADGNLHYNNGSWDEFANLLFVDQPVGTGFSYVNTDSYLTELDQMANHMVIFLEKWFGLFPEYEHDDLYIAGESYAGQHIPYIARAIVKRNKEQGKTPWALKGLLIGNGWISPVDQYLSYIPYAYQNGLMKADSDMAKRVENQQRICIKKLEDGGMDAVDTNDCEQIMVNILEETKDRKADRMNQCVNMYDIRLRDDASCGMNWPPDLASVTPYLRRPDVIQALHINPDKKTGWQECNGAVSGHFRAKKSEPSVRFLPELIPEVPTLLFSGDKDFICNHIGTEEMIKNMQWSGGKGFEVTPGVWAPKQDWTFEGEAAGSWQEARNLTYVVFYNSSHMVPFDYPRRTRDMLDRFMGVDIEQIGGVPSDSRIDGEKGPLTSVGDHPNSTRAEEDKATDVKQAEWKAYYRSGQVALVVVVIVAALWGIFLWRSRRRHTKTAYQGDDGDEGRESLLTGMGLDNFRRKERRSDLEAADFDERELDDLDGASKKPGNGYASLGSEKERQSHNDSTFSLGGDSDDEAGSSDGPKRKGGSS |
Enzyme Length | 641 |
Uniprot Accession Number | E5R540 |
Absorption | |
Active Site | ACT_SITE 182; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 382; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 444; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential release of a C-terminal arginine or lysine residue.; EC=3.4.16.6; |
DNA Binding | |
EC Number | 3.4.16.6 |
Enzyme Function | FUNCTION: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Glycosylation (4); Region (2); Signal peptide (1); Topological domain (2); Transmembrane (1) |
Keywords | Apoptosis;Carboxypeptidase;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..35; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 72,004 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |