| IED ID | IndEnz0002006558 |
| Enzyme Type ID | protease006558 |
| Protein Name |
Matrix metalloproteinase-A MMP-A MMP-Y19 EC 3.4.24.- Zinc metalloprotease 1 |
| Gene Name | zmp-1 EGAP1.3 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MFTGLHDILIILFLLVTLKIAQNVDHTKFLQKYGYLTSGDNQLSSESLSDALKNMQRMAGLEETGELDERTIQMMERPRCGHPDVEDHQKSRGKRYAPPQFKWKEKIITYGCKAVGTSTRISLDDLRRTMHQAASQWSELADVEIVESSVKNPMMVISAGRENHYPCTVRFDTKTLAHAFFPTNGQIHINDRVQFAMTNYTERMGANSLYSVVAHEMGHALGFSHSPDIDSVMFAYDTPRKWKFTSMDKYNMRSYYGAKASKKENEEEERKTENEDKRRKTEKDRGRTREHESDDIRPNECRVENPIVVQYRGEYLIFKSQWVWRVSSDWKRLIIKAVPINQLFPGLPNPIDAAVTVGHNLWVFVGEMIYVIYGNHMVHAPLRLSDIGINEKYVDLAYEWHYFNPPAVYIWKGSRYWKLDEKMYHRRVDERYPKDTDLNWARVPKGVHSAFTYEKEIHLLRGNQVFRMNSSRSVFDIADGYPQPLQSFFGFCPRNEKLVLNSSSSHFSLIYATITILILIF |
| Enzyme Length | 521 |
| Uniprot Accession Number | G5EGM1 |
| Absorption | |
| Active Site | ACT_SITE 216; /evidence=ECO:0000250|UniProtKB:P09238 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium. {ECO:0000269|PubMed:15960981}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (2); Metal binding (4); Motif (1); Propeptide (1); Region (1); Repeat (3); Signal peptide (1); Topological domain (1); Transmembrane (1) |
| Keywords | Cell membrane;Cleavage on pair of basic residues;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15960981}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:15960981}. Note=Localizes to puncta on the cell surface that are often concentrated at the invasive basolateral membrane of the anchor cell. {ECO:0000269|PubMed:15960981}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 12097347; 12710959; 14516686; 17164286; 17486083; 18085825; 19343510; 19686680; 21085631; 21177967; 21367940; 22267497; 22347378; 22560298; 23800452; 24884423; 25281934; 25487147; 6593563; |
| Motif | MOTIF 78..85; /note=Cysteine switch; /evidence=ECO:0000250|UniProtKB:P03956 |
| Gene Encoded By | |
| Mass | 60,700 |
| Kinetics | |
| Metal Binding | METAL 80; /note=Zinc; in inhibited form; /evidence=ECO:0000250|UniProtKB:P03956; METAL 215; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P03956; METAL 219; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P03956; METAL 225; /note=Zinc; catalytic; /evidence=ECO:0000250|UniProtKB:P03956 |
| Rhea ID | |
| Cross Reference Brenda |