| IED ID | IndEnz0002006641 |
| Enzyme Type ID | protease006641 |
| Protein Name |
Kallikrein-5 EC 3.4.21.- Kallikrein-like protein 2 KLK-L2 Stratum corneum tryptic enzyme |
| Gene Name | KLK5 SCTE UNQ570/PRO1132 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS |
| Enzyme Length | 293 |
| Uniprot Accession Number | Q9Y337 |
| Absorption | |
| Active Site | ACT_SITE 108; /note=Charge relay system; /evidence=ECO:0000269|PubMed:17881000; ACT_SITE 153; /note=Charge relay system; /evidence=ECO:0000269|PubMed:17881000; ACT_SITE 245; /note=Charge relay system; /evidence=ECO:0000269|PubMed:17881000 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by Zn2+. {ECO:0000269|PubMed:17881000}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: May be involved in desquamation. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (17); Chain (1); Disulfide bond (6); Domain (1); Erroneous gene model prediction (1); Erroneous initiation (1); Glycosylation (4); Helix (4); Natural variant (2); Region (1); Signal peptide (1); Site (1); Turn (2) |
| Keywords | 3D-structure;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal |
| Interact With | P20930; Q9NQG1 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (3) |
| Cross Reference PDB | 2PSX; 2PSY; 6QFE; |
| Mapped Pubmed ID | 11948967; 12385949; 12738725; 12890555; 15140227; 15654974; 15675955; 15713679; 15766562; 16517595; 16628198; 17012259; 17158887; 17459052; 17515931; 17596512; 17625593; 18163887; 18221492; 18843291; 19085836; 19118981; 19190824; 19383346; 19453546; 19558318; 19560453; 20090765; 20179351; 20424135; 20657595; 20667819; 20940292; 21163944; 21273346; 21741862; 21868565; 21997417; 22102857; 22505519; 23612974; 23629652; 24158494; 24534191; 25640309; 25926655; 26022646; 26345898; 26390218; 27430713; 28238749; 28615200; 28685545; 29107298; 29561728; 29883316; 30755669; 30759066; 31045568; 31307411; 33588911; 33896830; 34582061; |
| Motif | |
| Gene Encoded By | |
| Mass | 32,020 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.B39; |