| IED ID | IndEnz0002006651 |
| Enzyme Type ID | protease006651 |
| Protein Name |
Potassium voltage-gated channel subfamily KQT member 3 KQT-like 3 Potassium channel subunit alpha KvLQT3 Voltage-gated potassium channel subunit Kv7.3 |
| Gene Name | KCNQ3 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI |
| Enzyme Length | 872 |
| Uniprot Accession Number | O43525 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. {ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:14534157, ECO:0000269|PubMed:16319223, ECO:0000269|PubMed:9872318}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Chain (1); Compositional bias (2); Erroneous initiation (1); Helix (2); Intramembrane (1); Modified residue (2); Motif (1); Mutagenesis (3); Natural variant (8); Region (4); Sequence caution (1); Sequence conflict (2); Topological domain (8); Transmembrane (6) |
| Keywords | 3D-structure;Alternative splicing;Cell membrane;Disease variant;Epilepsy;Ion channel;Ion transport;Membrane;Phosphoprotein;Potassium;Potassium channel;Potassium transport;Reference proteome;Transmembrane;Transmembrane helix;Transport;Ubl conjugation;Voltage-gated channel |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10788442}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | MOD_RES 81; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:O88944; MOD_RES 246; /note=Phosphothreonine; /evidence=ECO:0000269|PubMed:16319223 |
| Post Translational Modification | PTM: KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation (Probable). Degradation induced by NEDD4L is inhibited by USP36 (PubMed:27445338). {ECO:0000269|PubMed:27445338, ECO:0000305|PubMed:27445338}. |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 5J03; |
| Mapped Pubmed ID | 10996506; 11427698; 11470829; 11724816; 12524525; 12640002; 12832524; 12928862; 15304482; 15483133; 16235065; 16525039; 16721610; 16735477; 16990515; 18089837; 18166285; 18249525; 18425618; 18625963; 18676988; 18786918; 18790849; 19112491; 19464834; 19913121; 20379614; 20393197; 20610766; 21231794; 21730298; 21976501; 21980481; 22334706; 22447848; 23002961; 23209695; 24375629; 24843134; 25041603; 25278462; 25524373; 25740509; 25998125; 26627826; 26692086; 26969140; 27607834; 29474891; 29748663; 30348901; 30885609; 31177578; 32580997; 33037390; 9278538; |
| Motif | MOTIF 316..321; /note=Selectivity filter; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 96,742 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |