| IED ID | IndEnz0002006680 |
| Enzyme Type ID | protease006680 |
| Protein Name |
Bradykinin-potentiating peptide K12 BPP-K12 Peptide K-12 Non-disulfide-bridged peptide 1.2 NDBP-1.2 |
| Gene Name | |
| Organism | Buthus occitanus (Common European scorpion) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Buthus Buthus occitanus (Common European scorpion) |
| Enzyme Sequence | LRDYANRVINGGPVEAAGPPA |
| Enzyme Length | 21 |
| Uniprot Accession Number | Q9TWD3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits angiotensin-converting enzyme (ACE), but does not serve as substrate for the enzyme. Potentiate bradykinin (BK) on the isolated guinea pig ileum as well as the isolated rat uterus for contraction. Also potentiates in vivo the depressor effect of BK on arterial blood pressure in the normotensive anesthetized rat. Intracerebroventricular injection into mice does not show toxic activity. {ECO:0000269|PubMed:8745044}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Peptide (1); Region (1) |
| Keywords | Direct protein sequencing;Hypotensive agent;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Secreted |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8745044}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 2,137 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |