| IED ID |
IndEnz0002006685 |
| Enzyme Type ID |
protease006685 |
| Protein Name |
Odorant response abnormal protein 4
|
| Gene Name |
odr-4 Y102E9.1 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MTRNRRKSKTTATSHPELHLEKVDPMKTVTESMILFDVQLQEWVTKSAKNHEFVLSDKGIPASAYFLLGSFCSDGDIHVAYASKCPVHSSALEENATESSKMLEDEWMSDHAERLLRMLPGGIHVVGIAWFSDKKTFSDRKSHIHKTLGRIQKMNNQITTANVDDSISDNMITVFFETPSTTPIGAIIDVTNRGNDSAQKVQFQKLEWISLVTNASARIVHNVPVDTGRPTDFYSDLVVATKNFVNNLFQCEFTLLDGEIRDDKEPLIKDIKKNKKTTIEAQLFLNPLYNRELGAIDDIASNMHEVLFDIEVRAAVPIRSTVKDAIRAIKHHLVRNLFARVELHYESMEVVEEERSPKTGITVHQLPRPATTVLYTHPAILINDFLFEADNVEDAQKNFDDMMDLQTSIEHVDEGWERALTPEEMEAVRTPIEDLHFVDFDGSSDSWCTTKTILITIALIIGLLASIIYFTVAHS |
| Enzyme Length |
475 |
| Uniprot Accession Number |
Q8I7F8 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: Required, with oct-8, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC (PubMed:9590179, PubMed:24603482). Regulates chemotaxis responses to benzaldehyde, diacetyl and 2,4,5-trimethylthiazole in AWA and AWC neurons (PubMed:8348618). Plays a role in nociceptive neurons to mediate avoidance of high oxygen (PubMed:16581509). {ECO:0000269|PubMed:16581509, ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:8348618, ECO:0000269|PubMed:9590179}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (3); Chain (1); Transmembrane (2) |
| Keywords |
Alternative splicing;Cell projection;Chemotaxis;Cytoplasmic vesicle;Endoplasmic reticulum;Golgi apparatus;Membrane;Olfaction;Reference proteome;Sensory transduction;Transmembrane;Transmembrane helix |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Note=Punctate expression in dendrite and axons. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10517638;
18524955;
20439776;
21085631;
21177967;
21367940;
22286215;
22560298;
22683808;
23800452;
24646679;
25487147;
|
| Motif |
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| Gene Encoded By |
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| Mass |
53,697 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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