| IED ID |
IndEnz0002006692 |
| Enzyme Type ID |
protease006692 |
| Protein Name |
Plasminogen activator inhibitor 1
PAI
PAI-1
Endothelial plasminogen activator inhibitor
Serpin E1
|
| Gene Name |
Serpine1 Mr1 Pai1 Planh1 |
| Organism |
Mus musculus (Mouse) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Mus
Mus
Mus musculus (Mouse)
|
| Enzyme Sequence |
MQMSSALACLILGLVLVSGKGFTLPLRESHTAHQATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQRDTLSMFIAAPFEKDVHLSALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTETILFMGQVMEP |
| Enzyme Length |
402 |
| Uniprot Accession Number |
P22777 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (By similarity). Involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (PubMed:28722352). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity). {ECO:0000250|UniProtKB:P05121, ECO:0000269|PubMed:16862142, ECO:0000269|PubMed:28722352}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (14); Chain (1); Glycosylation (3); Helix (12); Sequence conflict (1); Signal peptide (1); Site (1); Turn (4) |
| Keywords |
3D-structure;Direct protein sequencing;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With |
Q5S248 |
| Induction |
INDUCTION: Expression in the liver oscillates in a circadian manner. {ECO:0000269|PubMed:23291174}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05121}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..22; /evidence=ECO:0000305|PubMed:7523120 |
| Structure 3D |
X-ray crystallography (1) |
| Cross Reference PDB |
3LW2;
|
| Mapped Pubmed ID |
10318667;
10368124;
10515791;
10627465;
10712412;
10716993;
10752934;
10821760;
10891445;
10992299;
11059781;
11104787;
11110693;
11141484;
11154109;
11157667;
11213252;
11292663;
11441025;
11470783;
11473641;
11481248;
11557572;
11641723;
11696429;
11779826;
11792849;
11818362;
11884297;
12067901;
12070304;
12074598;
12208516;
12414527;
12482822;
12524228;
12536348;
12598326;
12603314;
12615902;
12702502;
12761249;
12818888;
12832488;
12853975;
12875966;
12897066;
14512369;
14581407;
14625301;
14645112;
14747283;
14963029;
14982862;
15116271;
15166500;
15242553;
15284078;
15286708;
15297377;
15308506;
15328353;
15361354;
15562441;
15569940;
15674349;
15716324;
15730388;
15780082;
15869599;
15886793;
15944322;
15946208;
15978095;
15978107;
16144810;
16148154;
16148222;
16160004;
16194205;
16221737;
16250054;
16314510;
16316341;
16373605;
16427606;
16460449;
16514083;
16528256;
16601674;
16625420;
16676075;
16735799;
16750510;
16785241;
16813566;
16839355;
16843437;
16879220;
16887829;
16931518;
16940168;
16943282;
16985520;
17018527;
17022820;
17032919;
17062126;
17067365;
17068293;
17082641;
17114493;
17230448;
17415547;
17429342;
17431190;
17439629;
17495424;
17561000;
17576591;
17596132;
17652357;
17656680;
17717143;
17723219;
17726492;
17848179;
17888748;
17938813;
17958748;
18095342;
18216319;
18255094;
18258607;
18276785;
18359942;
18395096;
18469330;
18551132;
18554148;
18559377;
18597060;
18614541;
18622550;
18689689;
18723692;
18753414;
18800031;
18813358;
18820962;
18835034;
18925475;
18957535;
18990706;
19060228;
19098125;
19106220;
19122176;
19144865;
19168071;
19190826;
19338064;
19429749;
19443721;
19461880;
19487690;
19492148;
19498055;
19604604;
19628967;
19718486;
19745198;
19786738;
19812386;
19855083;
19887897;
20009036;
20133625;
20133900;
20147383;
20171267;
20185832;
20203062;
20228065;
20230900;
20232379;
20300183;
20351105;
20492459;
20501949;
20519507;
20522601;
20561659;
20630999;
20810696;
20823384;
20854792;
20969520;
21042733;
21119013;
21139380;
21146630;
21239537;
21267068;
21354214;
21423135;
21496886;
21501583;
21546607;
21571686;
21596853;
21622848;
21667402;
21707474;
21724997;
21734232;
21757225;
21768189;
21819560;
21829547;
21880664;
21926267;
21945446;
21969564;
22046433;
22078208;
22178065;
22213800;
22262246;
22293605;
22307671;
22383705;
22432023;
22484384;
22507835;
22560297;
22563394;
22570200;
22572461;
22573404;
22658637;
22723298;
22912336;
22952059;
22982464;
22984202;
23079293;
23082983;
23213481;
23218129;
23249568;
23254194;
23340304;
23408987;
23454124;
23461356;
23487423;
23494120;
23565059;
23657855;
23665346;
23708702;
23712751;
23715621;
23724005;
23770230;
23776165;
23816469;
23894536;
23919993;
23940734;
23991045;
24006456;
24019535;
24024554;
24107419;
24155177;
24212262;
24269585;
24425831;
24440681;
24478370;
24605827;
24651693;
24655755;
24667608;
24709679;
24778222;
24929950;
24962629;
24987792;
25041188;
25077763;
25106729;
25356654;
25399881;
25447049;
25451236;
25454795;
25552599;
25587125;
25613478;
25673638;
25679759;
25715398;
25740294;
25799354;
25932922;
26032256;
26053644;
26349765;
26414805;
26416771;
26471094;
26747783;
26984772;
27038741;
27106291;
27120339;
27283026;
27317488;
27377187;
27404230;
27436577;
27659097;
27770432;
27793937;
27906548;
27924807;
28132883;
28270519;
28273432;
28321652;
28336948;
28385810;
28432216;
28445073;
28588076;
28684544;
28693719;
28821477;
28893232;
28899878;
28924605;
29028290;
29371242;
29391420;
29454747;
29477725;
29534207;
29561836;
29584619;
29643421;
29978354;
30087332;
30124738;
30220231;
30387130;
30463014;
30532990;
30566624;
30842312;
30855280;
31054988;
31230745;
31424116;
31513752;
31610810;
31676865;
32001531;
32024545;
32142912;
32178735;
32272863;
32657780;
32928888;
33097058;
33665549;
33673196;
33866038;
33904394;
34680110;
7743917;
8254028;
8254029;
8397803;
8424466;
8550840;
8550848;
8560424;
8618918;
8639841;
8662686;
8798151;
8816919;
8939962;
8959348;
9033272;
9119016;
9386191;
9427542;
9701244;
9701458;
9727060;
9733098;
9892694;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
45,170 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|