| IED ID | IndEnz0002006695 |
| Enzyme Type ID | protease006695 |
| Protein Name |
Genome-linked protein precursor Cleaved into: Serine protease EC 3.4.21.- ; VPg |
| Gene Name | ORF2 |
| Organism | Poinsettia latent virus (isolate Euphorbia pulcherrima/Germany/Siepen/2005) (PnLV) (Poinsettia cryptic virus) |
| Taxonomic Lineage | Viruses Riboviria Orthornavirae Pisuviricota Pisoniviricetes Sobelivirales Solemoviridae Polemovirus Poinsettia latent virus Poinsettia latent virus (isolate Euphorbia pulcherrima/Germany/Siepen/2005) (PnLV) (Poinsettia cryptic virus) |
| Enzyme Sequence | MALLGIKLMTLVFAAWLSCCHSSSALPSSGLSGPCLNHSCLLRNSLNGASQWGTILHSPAVGSNCPPCPMMSIMGCSPPKPLQSNSYGVLCSTIASKAKQDLKLCWKEVQTRSEMYSKRISAALIDSLHQAVGMLLMIIIWIWSSIFLVVYHVLAYMTTYHLSSAVCVGFLIFCTICAFRLISWICGDLLAFNVSGLTPIWVNFSESSCPAGLSLRRYKNEKTVEGYKPFIIPQKSPKKSVIELSFSNGSHLGYATCVRLWDGSICLMTAKHCLVKEALLKGRVAGHSLPVKNFDLFLTCDEIDFSLLRGPKQWEAYLGVKGADLITSNRIGRSPVTFYNLSKDGEWLANSAQITGRHGKLCSVLSNTSPGDSGTPYYSGKNVVGIHKGTSELENYNLMIPIPNIPGLTSPDFKFETTNVRGNLYNDEGFRLSVGEDDKAEHWTDRLMKSITFKTKRWADWAEEESESDDERGKVVPPAKPSNYGEGCPPEHNQYLSDVGDLLTKVIGPEQNEKCVDILMGIMGVDKNEVAPHKEEKAEKGNEAVVSATVKTVKEPTTQCDEDIISEIVKRVVDKMNLKAIEKSVVEILAEKAMTKAPRGKRKNSKDTSRPSTPGSYIIPAKRTPDSGPVEKSLNSTGRAKEESPSGARTLPGNIPAWVR |
| Enzyme Length | 660 |
| Uniprot Accession Number | Q5NDN0 |
| Absorption | |
| Active Site | ACT_SITE 272; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01216; ACT_SITE 304; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01216; ACT_SITE 373; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01216 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (3); Compositional bias (1); Domain (1); Region (2); Signal peptide (1); Site (2); Transmembrane (2) |
| Keywords | Host membrane;Hydrolase;Membrane;Protease;Reference proteome;Ribosomal frameshifting;Serine protease;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 72,353 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |