| IED ID |
IndEnz0002006709 |
| Enzyme Type ID |
protease006709 |
| Protein Name |
pH-response transcription factor pacC/RIM101
|
| Gene Name |
pacC |
| Organism |
Acremonium chrysogenum (Cephalosporium acremonium) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
sordariomyceta
Sordariomycetes
Hypocreomycetidae
Hypocreales
Hypocreales incertae sedis
Acremonium
Acremonium chrysogenum (Cephalosporium acremonium)
|
| Enzyme Sequence |
MSPPAPDAQPSSGSSSDNSNADSKSTTPPPPSSTTSTTSAAAISAAVVPDDNLTCRWNACNQKFPNPETLYDHICERHVGRKSTNNLNLTCQWNSCRTTTVKRDHITSHIRVHVPLKPHKCEFCGKSFKRPQDLKKHVKTHADDSVLVRPSQDNHNQGGMNYRPHLNKTPSYYDHNGQMRTQYQHHQPAHPNAYYAPQPSTNYGLYFNQPPLNNHQRTEHLGYGAPPGGYDRKRAFDMVDDFFSSAKRREIDPSSYSQIGRSLLPLHGTLSIPSGPMPATEQHYVPQPQHAGIAHAGPAPTQNPLAQQYYLPMPPNARTQKDLVQIDNLLGQMQDTIYENANHATAGVQIHHGHDHYSGYRSSQSPPIAQRGSPGGMPVGPDGYHQPVSAATMASPLTAMSSTGTPAVTPPSSAVSYTSGHSPSPSAPAMSPQSRHSSTSGSVMYPSLPTSLPAVSQGFGQSTTTTLGPSFESNERRRYSGGMLQRARAAPPRSTDNHNHNHNHGASTPKAPVSPALASPSSEVSDVSEATREREEQYDRWLENMRVIESLREYVRGRLERREYVEEQENEHQGQGEAARKERDGNPMDVDARSPRSPAREQPGRPREGSSLYPILRMPGD |
| Enzyme Length |
621 |
| Uniprot Accession Number |
Q96X49 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. {ECO:0000269|PubMed:11405634}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (4); Motif (2); Region (4); Zinc finger (3) |
| Keywords |
Cytoplasm;Metal-binding;Nucleus;Repeat;Repressor;Zinc;Zinc-finger |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}. |
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 445..448; /note=YPX[LI] motif 1; MOTIF 613..616; /note=YPX[LI] motif 2 |
| Gene Encoded By |
|
| Mass |
68,151 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|