| IED ID |
IndEnz0002006711 |
| Enzyme Type ID |
protease006711 |
| Protein Name |
pH-response transcription factor pacC/RIM101
|
| Gene Name |
pacC AFUA_3G11970 |
| Organism |
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
Eurotiomycetes
Eurotiomycetidae
Eurotiales (green and blue molds)
Aspergillaceae
Aspergillus
Aspergillus subgen. Fumigati
Neosartorya fumigata (Aspergillus fumigatus)
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
|
| Enzyme Sequence |
MSEHQDTATNNNTTASPSATAAPMPAPISQEQPSSQPAATTPAPVSTSTPPASVTATAAAATAAVSAPQANGTPPSDEQLSCLWQGCSEKCPSAEALYDHICERHVGRKSTNNLNLTCQWGSCRTTTVKRDHITSHIRVHVPLKPHKCEFCGKAFKRPQDLKKHVKTHADDSVLVRSPEPGARNPDMMFHGAGKGYAAAAHYFEPSLNAVPSQGYAHGAPQYYSSHPPHQPSNPSYGNVYYALNHGHDGHASYESKKRGYDALNEFFGDLKRRQFDLHSYAAVGQRLLGLQNLSLPILTGGPLPEYQPMPAPVAVGGGYGPGGHGAPVYHLPPMSNIRTKNDLINIDQFLQQMQDTIYENDDHVAAAGVAQPGAHYVHGGMSYRTTHSPPTQLPPSHAVATTSASTSMSNPATHSPPTGTPALTPPSSAQSYTSARSPISISSAHRVSPPHHDGGSGMYPRLPSTTMADSLAGGYPTASSAAPPSTLSGIFDDDRRRYTGGTLQRARPEERRPSIQMDTSHDGKEDGERTPTGKARSSGSDSPVRISANLIDPALHSSSPSDAEAALRTAQAATEVADRADSQWVEKVRLLEYLRSYIASRLERGEYDSDSDDHASAAASPVIKHDGHMDGVESSHKPITAEETSAPPAAKAESNHGVMYPTLHGLDGDEDTKMHH |
| Enzyme Length |
676 |
| Uniprot Accession Number |
Q4WY67 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes (By similarity). {ECO:0000250}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (3); Motif (2); Region (3); Sequence conflict (4); Zinc finger (3) |
| Keywords |
Activator;Cytoplasm;DNA-binding;Metal-binding;Nucleus;Reference proteome;Repeat;Repressor;Transcription;Transcription regulation;Zinc;Zinc-finger |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}. |
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 459..462; /note=YPX[LI] motif 1; MOTIF 660..663; /note=YPX[LI] motif 2 |
| Gene Encoded By |
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| Mass |
71,949 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
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