| IED ID | IndEnz0002006770 |
| Enzyme Type ID | protease006770 |
| Protein Name |
Derlin-2 Degradation in endoplasmic reticulum protein 2 DERtrin-2 Der1-like protein 2 F-LAN-1 F-LANa |
| Gene Name | DERL2 DER2 FLANA CGI-101 SBBI53 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGHIYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG |
| Enzyme Length | 239 |
| Uniprot Accession Number | Q9GZP9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:26565908}.; FUNCTION: (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. {ECO:0000269|PubMed:15215855}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Frameshift (1); Region (1); Topological domain (5); Transmembrane (4) |
| Keywords | Endoplasmic reticulum;Host-virus interaction;Membrane;Reference proteome;Transmembrane;Transmembrane helix;Unfolded protein response |
| Interact With | Q9NR28; Q9H0Q3; P60409; P60410; Q00013; P43378; Q8N0V3; Q8WV19 |
| Induction | INDUCTION: Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). {ECO:0000269|PubMed:16449189}. |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11146634; 11812794; 15611333; 16901789; 16912321; 18264092; 18417469; 18502753; 18711132; 18716059; 19002207; 1998343; 20467438; 21357747; 23232094; 23867461; 24019521; 24685677; 2475911; 25416956; 2570460; 26107514; 26496610; 26638075; 29167172; 33980593; 7523390; 7529176; 7553863; 7553864; |
| Motif | |
| Gene Encoded By | |
| Mass | 27,567 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |