| IED ID | IndEnz0002006777 |
| Enzyme Type ID | protease006777 |
| Protein Name |
ATP-dependent zinc metalloprotease FTSH 4, mitochondrial AtFTSH4 EC 3.4.24.- |
| Gene Name | FTSH4 At2g26140 T19L18.5 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MAWRRIITKVSSHERELSSLRSLLVRAYSSFPRVGVTGAVGGGGASLPRTRFQSSYVGSFARRVRDREEVNEVAHLRELIRRNDPEAVIRMFESQPSLHANASALSEYIKALVKVDRLDQSELVRTLQRGIAGVAREEETFGGLGAFRNVGKPTKDGVLGTASAPIHTISTERTHFKEQLWSTIRTIGVGFLLISGIGALIEDRGIGKGLGLHEEVQPSMDSSTKFSDVKGVDEAKAELEEIVHYLRDPKRFTRLGGKLPKGVLLVGPPGTGKTMLARAIAGEAGVPFFSCSGSEFEEMFVGVGARRVRDLFSAAKKCSPCIIFIDEIDAIGGSRNPKDQQYMKMTLNQMLVELDGFKQNEGIIVVAATNFPESLDKALVRPGRFDRHIVVPNPDVEGRRQILESHMSKVLKAEDVDLMIIARGTPGFSGADLANLVNVAALKAAMDGSKDVTMSDLEFAKDRIMMGSERKSAVISDESRKLTAFHEGGHALVAIHTEGALPVHKATIVPRGMALGMVSQLPDKDETSISRKQMLARLDVCMGGRVAEELIFGESEVTSGASSDLEQATKLARAMVTKFGMSKEVGLVAHNYDDNGKSMSTETRLLIESEVKQLLEKAYNNAKTILTVYNKELHALANALLQHETLSGKQIKELLTDLNSPLLQKRQEVVTKQSNPVPPSTPSSASSAAAAAAAAAAAAAAAAATAATKGKDMAPVS |
| Enzyme Length | 717 |
| Uniprot Accession Number | O80983 |
| Absorption | |
| Active Site | ACT_SITE 487; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Probable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complex V of the mitochondrial oxidative phosphorylation system. {ECO:0000269|Ref.9}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 267..274; /note=ATP; /evidence=ECO:0000255 |
| Features | Active site (1); Chain (1); Metal binding (3); Nucleotide binding (1); Transit peptide (1); Transmembrane (1) |
| Keywords | ATP-binding;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Nucleotide-binding;Protease;Reference proteome;Transit peptide;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | INDUCTION: By high light. {ECO:0000269|PubMed:15266057}. |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:16247555, ECO:0000269|Ref.9, ECO:0000305|PubMed:25732537}; Single-pass membrane protein {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:16247555, ECO:0000269|Ref.9}; Intermembrane side {ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:16247555, ECO:0000269|Ref.9}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12185496; 16618929; 17181860; 17432890; 18493073; 18545707; 18775970; 19453455; 20009533; 20193658; 22121866; 22986791; 24482432; 25763704; 27297677; 27321362; 27404356; 28250067; 28264925; 29156584; 29538317; 29963070; |
| Motif | |
| Gene Encoded By | |
| Mass | 77,275 |
| Kinetics | |
| Metal Binding | METAL 486; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 490; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 564; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.24.B19;3.4.24.B20; |