| IED ID |
IndEnz0002006803 |
| Enzyme Type ID |
protease006803 |
| Protein Name |
Hirudin-HM1
|
| Gene Name |
|
| Organism |
Poecilobdella manillensis (Mexican medical leech) (Hirudinaria manillensis) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Spiralia
Lophotrochozoa
Annelida
Clitellata
Hirudinea (leeches)
Hirudinida
Hirudiniformes
Hirudinidae
Poecilobdella
Poecilobdella manillensis (Mexican medical leech) (Hirudinaria manillensis)
|
| Enzyme Sequence |
MFSLKLFVVFLAVCICVSQAVSYTDCTESGQNYCLCVGGNLCGGGKHCEMDGSGNKCVDGEGTPKPKSQTEGDFEEIPDEDILN |
| Enzyme Length |
84 |
| Uniprot Accession Number |
Q07558 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (3); Glycosylation (1); Region (3); Signal peptide (1) |
| Keywords |
Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..20; /evidence=ECO:0000269|PubMed:7685281 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
8,934 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|