| IED ID | IndEnz0002006887 |
| Enzyme Type ID | protease006887 |
| Protein Name |
Calpain small subunit 2 CSS2 Calcium-dependent protease small subunit 2 |
| Gene Name | Capns2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MFLAKAILEGADRGLGGALGGLLGGGGQARAGGGNIGGILGGIVNFISEAAAAQYTPEPPPQQQHFTVVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKELKTEGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVFKQYDSDHSGSLGSSQLHGAMQAAGFQLNEQLYLMIVRRYADEDGGMDFNNFISCLVRLDAMFRAFKALDRDRDGLIQVSIREWLQLTMYS |
| Enzyme Length | 247 |
| Uniprot Accession Number | Q9D7J7 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 87..98; /note="1"; /evidence="ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448"; CA_BIND 131..142; /note="2"; /evidence="ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448"; CA_BIND 161..172; /note="3"; /evidence="ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448" |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Calcium binding (3); Chain (1); Domain (4); Metal binding (12) |
| Keywords | Calcium;Cell membrane;Cytoplasm;Membrane;Metal-binding;Reference proteome;Repeat |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; 17646163; |
| Motif | |
| Gene Encoded By | |
| Mass | 27,190 |
| Kinetics | |
| Metal Binding | METAL 88; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 91; /note=Calcium 1; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 93; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 131; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 133; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 135; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 137; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 142; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 161; /note=Calcium 3; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 163; /note=Calcium 3; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 165; /note=Calcium 3; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 204; /note=Calcium 4; /evidence=ECO:0000250|UniProtKB:Q64537 |
| Rhea ID | |
| Cross Reference Brenda |