| IED ID | IndEnz0002006905 |
| Enzyme Type ID | protease006905 |
| Protein Name |
Murein hydrolase activator EnvC Septal ring factor |
| Gene Name | envC yibP b3613 JW5646 |
| Organism | Escherichia coli (strain K12) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli (strain K12) |
| Enzyme Sequence | MTRAVKPRRFAIRPIIYASVLSAGVLLCAFSAHADERDQLKSIQADIAAKERAVRQKQQQRASLLAQLKKQEEAISEATRKLRETQNTLNQLNKQIDEMNASIAKLEQQKAAQERSLAAQLDAAFRQGEHTGIQLILSGEESQRGQRLQAYFGYLNQARQETIAQLKQTREEVAMQRAELEEKQSEQQTLLYEQRAQQAKLTQALNERKKTLAGLESSIQQGQQQLSELRANESRLRNSIARAEAAAKARAEREAREAQAVRDRQKEATRKGTTYKPTESEKSLMSRTGGLGAPRGQAFWPVRGPTLHRYGEQLQGELRWKGMVIGASEGTEVKAIADGRVILADWLQGYGLVVVVEHGKGDMSLYGYNQSALVSVGSQVRAGQPIALVGSSGGQGRPSLYFEIRRQGQAVNPQPWLGR |
| Enzyme Length | 419 |
| Uniprot Accession Number | P37690 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein. {ECO:0000269|PubMed:11976287, ECO:0000269|PubMed:15165230, ECO:0000269|PubMed:19525345, ECO:0000269|PubMed:20300061, ECO:0000269|PubMed:23796240}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (11); Chain (1); Coiled coil (2); Compositional bias (1); Erroneous initiation (1); Helix (1); Mutagenesis (9); Region (1); Signal peptide (1) |
| Keywords | 3D-structure;Cell cycle;Cell division;Coiled coil;Periplasm;Reference proteome;Signal |
| Interact With | P0AC30 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:12113939, ECO:0000269|PubMed:15165230, ECO:0000269|PubMed:19525345}. Note=Localizes at the septal ring. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..34; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 4BH5; 6TPI; |
| Mapped Pubmed ID | 318637; 33097670; 352222; 378695; 3890689; 4218460; 4574921; 6120994; 6384425; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,595 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |