| IED ID | IndEnz0002006920 |
| Enzyme Type ID | protease006920 |
| Protein Name |
Glutamyl endopeptidase EC 3.4.21.19 Glutamic acid-specific protease GluSE |
| Gene Name | gseA SERP1397 |
| Organism | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus epidermidis Staphylococcus epidermidis (strain ATCC 35984 / RP62A) |
| Enzyme Sequence | MKKRFLSICTMTIAALATTTMVNTSYAKTDTESHNHSSLGTENKNVLDINSSSHNIKPSQNKSYPSVILPNNNRHQIFNTTQGHYDAVSFIYIPIHGGYMSGSGVVVGENEILTNKHVVNGAKGNPRNISVHPSAKNENDYPNGKFVGQEIIPYPGNSDLAILRVSPNEHNQHIGQVVKPATISSNTDTRINENITVTGYPGDKPLATMWESVGKVVYIGGEELRYDLSTVGGNSGSPVFNGKNQVIGIHYGGVDNKYNSSVYINDFVQQFLRNNIPDINIQ |
| Enzyme Length | 282 |
| Uniprot Accession Number | Q5HN75 |
| Absorption | |
| Active Site | ACT_SITE 117; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083; ACT_SITE 159; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083; ACT_SITE 235; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Glu-|-Xaa, Asp-|-Xaa.; EC=3.4.21.19; Evidence={ECO:0000255|PROSITE-ProRule:PRU10083}; |
| DNA Binding | |
| EC Number | 3.4.21.19 |
| Enzyme Function | FUNCTION: Exhibits a significant hydrolytic activity for the carbonyl side of glutamic acid. Shows activity toward human fibronectin and type 1 collagen (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Propeptide (1); Signal peptide (1) |
| Keywords | Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Virulence;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 32298574; |
| Motif | |
| Gene Encoded By | |
| Mass | 30,831 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |