| IED ID | IndEnz0002006951 |
| Enzyme Type ID | protease006951 |
| Protein Name |
Serine protease Do-like HtrA EC 3.4.21.107 |
| Gene Name | htrA |
| Organism | Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Lactobacillus helveticus (Lactobacillus suntoryeus) |
| Enzyme Sequence | MVENQNNNQNQPRKKSGNKIIATAAIFGVVGGLVGGGVSYYAMDQMNNGQGNGAAQISISSSSSKVSEKSAKNGGTMTAAYNDVKGAVVSVINLKRQSASSGTDSLYNSLFGDDSDSSSSKNGKLETYSEGSGVVYMKSNGKGYIVTNNHVISGSDAVQVLLANGKTVNAKVVGKDSTTDLAVLSIDAKYVTQTAQFGDSKHLEAGQTVIAVGSPLGSEYASTVTQGIISAPARTISTSSGNQQTVIQTDAAINPGNSGGALVNSAGQVIGINSMKLAQSSDGTSVEGMAFAIPSNEVVTIVNELVKKGKITRPQLGVRVIALQGIPEGYRSRLKIKSNLKNGIYIAFVSRNGSAANAGIKSGDVITKVDGKKVEDVASLHSILYSHKVGDTVNVTVNRNGKDVDMKVKLEGN |
| Enzyme Length | 413 |
| Uniprot Accession Number | Q9Z4H7 |
| Absorption | |
| Active Site | ACT_SITE 150; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 180; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 258; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.; EC=3.4.21.107; |
| DNA Binding | |
| EC Number | 3.4.21.107 |
| Enzyme Function | FUNCTION: Degrades abnormal exported proteins and responsible for the propeptide processing of a natural pro-protein and for the maturation of a native protein. It also plays a prominent role in stress (heat shock, ethanol, puromycin and NaCl) resistance during active exponential growth (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (1); Region (2); Transmembrane (1) |
| Keywords | Cell membrane;Hydrolase;Membrane;Protease;Serine protease;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,647 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |