| IED ID | IndEnz0002006953 |
| Enzyme Type ID | protease006953 |
| Protein Name |
Intramembrane protease 2 EC 3.4.23.- |
| Gene Name | imp-2 T05E11.5 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MAEAATEIPPTASNVTVFTFEEQATSSLALYGMSILCIIIGSIRSAQYIRTNIDKKRLIEGSITMREARKFPISASLVLFGLYLFFKPAAERFLWVARVFQILRVPEEYVQKINSTIISYTANTTTTGPSEPFLLRLASRIPQERVPEAIQNAATYAYTNLPTIQKAECMQLLTFLICFEGVNAFASLLKPFVTAFLKKMPLVPSFLRFNAPYLFSLKKGNKEMEEGDIEDAKKKETEYLFKIDFDRYDIIALLMCSPILISHLLKRHWITNNIIGVSFSILGIERLHLASFKAGSLLLVGLFFYDIFWVFGTDVMTSVAKGIDAPILLQFPQDIYRNGIMEASKHSMLGLGDIVIPGIFIALLRRFDYRVVQTTAESKAPQGSLKGRYYFVVTVVAYMAGLFITMAVMHHFKAAQPALLYLVPCCLFVPLLLAVIRGELSALWNYDESRHVDNEENRKKVDSGKKNN |
| Enzyme Length | 468 |
| Uniprot Accession Number | P49049 |
| Absorption | |
| Active Site | ACT_SITE 306; /evidence=ECO:0000250|UniProtKB:P49768; ACT_SITE 353; /evidence=ECO:0000250|UniProtKB:P49768 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1 (PubMed:15469912). Involved in embryonic and larval development (PubMed:15469912, PubMed:29137240). {ECO:0000269|PubMed:15469912, ECO:0000269|PubMed:29137240, ECO:0000305|PubMed:29137240}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Glycosylation (3); Motif (1); Mutagenesis (4); Topological domain (10); Transmembrane (9) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12529635; 14551910; 15489339; 16184190; 21177967; 22560298; 23800452; 25487147; 27129311; 28089866; 29348603; 30036395; |
| Motif | MOTIF 417..419; /note=PAL; /evidence=ECO:0000250|UniProtKB:P49768 |
| Gene Encoded By | |
| Mass | 52,794 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |