Detail Information for IndEnz0002006958
IED ID IndEnz0002006958
Enzyme Type ID protease006958
Protein Name Serine protease inhibitor Kazal-type 6
Kallikrein inhibitor
Gene Name SPINK6 UNQ844/PRO1782
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MKLSGMFLLLSLALFCFLTGVFSQGGQVDCGEFQDPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC
Enzyme Length 80
Uniprot Accession Number Q6UWN8
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. {ECO:0000269|PubMed:20667819, ECO:0000269|PubMed:21439340}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (5); Chain (1); Disulfide bond (3); Domain (1); Helix (1); Modified residue (1); Natural variant (1); Signal peptide (1); Site (1); Turn (1)
Keywords 3D-structure;Direct protein sequencing;Disulfide bond;Protease inhibitor;Pyrrolidone carboxylic acid;Reference proteome;Secreted;Serine protease inhibitor;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BT20}.
Modified Residue MOD_RES 24; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000250|UniProtKB:P01001
Post Translational Modification
Signal Peptide SIGNAL 1..23; /evidence=ECO:0000269|PubMed:15340161
Structure 3D NMR spectroscopy (1)
Cross Reference PDB 2N52;
Mapped Pubmed ID 23303447; 24352040; 26828269; 27354280; 27671677; 27999203; 34099859;
Motif
Gene Encoded By
Mass 8,585
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda