IED ID | IndEnz0002006963 |
Enzyme Type ID | protease006963 |
Protein Name |
Low-density lipoprotein receptor LDL receptor |
Gene Name | Ldlr |
Organism | Rattus norvegicus (Rat) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
Enzyme Sequence | MSTADLMLRWAIALLLAAAGVAAEDSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWRCDGRTDCENGSDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCAATTCGPAHFRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGAEDTAAEVVSSPCSSLEFHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKDLKIGYECLCPSGFRLVDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVCKAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQGTSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIVLFHNVTQPRGVNWCEATVLPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGTSTIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHNEDPSATSTSRQPGDTPELSTVESVTVSSQVQGDMAGRGDEVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKTTEDEIHICRSQDGYTYPSRQMVSLEDDVA |
Enzyme Length | 879 |
Uniprot Accession Number | P35952 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. {ECO:0000250|UniProtKB:P01130}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1); Compositional bias (3); Disulfide bond (30); Domain (10); Glycosylation (4); Modified residue (5); Motif (1); Region (3); Repeat (6); Signal peptide (1); Topological domain (2); Transmembrane (1) |
Keywords | Cell membrane;Cholesterol metabolism;Coated pit;Disulfide bond;EGF-like domain;Endocytosis;Endosome;Glycoprotein;Golgi apparatus;LDL;Lipid metabolism;Lipid transport;Lysosome;Membrane;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Steroid metabolism;Sterol metabolism;Transmembrane;Transmembrane helix;Transport;Ubl conjugation |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01130}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01131}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P01130}. Golgi apparatus {ECO:0000250|UniProtKB:P01130}. Early endosome {ECO:0000250|UniProtKB:P01130}. Late endosome {ECO:0000250|UniProtKB:P01130}. Lysosome {ECO:0000250|UniProtKB:P01130}. Note=Rapidly endocytosed upon ligand binding. {ECO:0000250|UniProtKB:P01130}. |
Modified Residue | MOD_RES 717; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:16641100; MOD_RES 724; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:16641100; MOD_RES 732; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:16641100; MOD_RES 733; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:16641100; MOD_RES 734; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:16641100 |
Post Translational Modification | PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:P01130}.; PTM: Ubiquitinated by MYLIP leading to degradation. {ECO:0000250|UniProtKB:P01130}. |
Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000250|UniProtKB:P01131 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | 10468577; 12646183; 15044370; 16741953; 17256088; 17288738; 17572141; 18054320; 18703410; 19008317; 20028367; 22293196; 27378433; 28469073; 29459263; 3559401; |
Motif | MOTIF 842..847; /note=NPXY motif; /evidence=ECO:0000250|UniProtKB:P01130 |
Gene Encoded By | |
Mass | 96,622 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |