| IED ID | IndEnz0002007017 |
| Enzyme Type ID | protease007017 |
| Protein Name |
Haptoglobin-related protein Fragment |
| Gene Name | HPR |
| Organism | Pan troglodytes (Chimpanzee) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Pan (chimpanzees) Pan troglodytes (Chimpanzee) |
| Enzyme Sequence | DLGAVIYLLLWGRQLFALYSSNDVTDISDDRFPKPPEIANGYVEHLFRYQRKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSRHNLTTGATLINEQWLLTTAKNLFLSHSENATAKDSAPTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSNNFKLTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIHVWVQKTIAEN |
| Enzyme Length | 346 |
| Uniprot Accession Number | Q28801 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron. {ECO:0000250|UniProtKB:P00739}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Domain (2); Non-terminal residue (1); Sequence conflict (4); Signal peptide (1) |
| Keywords | Disulfide bond;Hemoglobin-binding;Reference proteome;Secreted;Serine protease homolog;Signal;Sushi |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00739}. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000250|UniProtKB:P00739}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL <1..16; /note=Not cleaved; /evidence=ECO:0000250|UniProtKB:P00739 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 38,867 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |