| IED ID | IndEnz0002007021 |
| Enzyme Type ID | protease007021 |
| Protein Name |
Intermediate cleaving peptidase 55, mitochondrial EC 3.4.11.- AtICP55 Protein INTERMEDIATE CLEAVAGE PEPTIDASE 55 |
| Gene Name | ICP55 At1g09300 T31J12.2 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MQFLARNLVRRVSRTQVVSRNAYSTQTVRDIGQPTPASHPHLMAEGEVTPGIRIEEYIGRRKKLVELLPENSLAIISSAPVKMMTDVVPYTFRQDADYLYLTGCQQPGGVAVLSDERGLCMFMPESTPKDIAWEGEVAGVDAASEVFKADQAYPISKLPEILSDMIRHSSKVFHNVQSASQRYTNLDDFQNSASLGKVKTLSSLTHELRLIKSPAELKLMRESASIACQGLLKTMLHSKGFPDEGILSAQVEYECRVRGAQRMAFNPVVGGGSNASVIHYSRNDQRIKDGDLVLMDMGCELHGYVSDLTRTWPPCGKFSSVQEELYDLILQTNKECIKQCKPGTTIRQLNTYSTELLCDGLMKMGILKSRRLYHQLNPTSIGHYLGMDVHDSSAVGYDRPLQPGFVITIEPGVYIPSSFDCPERFQGIGIRIEDDVLITETGYEVLTGSMPKEIKHIETLLNNHCHDNSARTSPVSLCKVKGLHTNRNPRRLF |
| Enzyme Length | 493 |
| Uniprot Accession Number | F4HZG9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.11.- |
| Enzyme Function | FUNCTION: Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome. {ECO:0000269|PubMed:25732537, ECO:0000269|PubMed:25862457}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Erroneous gene model prediction (1); Frameshift (2); Metal binding (7); Sequence conflict (1); Transit peptide (1) |
| Keywords | Alternative splicing;Aminopeptidase;Hydrolase;Manganese;Metal-binding;Metalloprotease;Mitochondrion;Nucleus;Protease;Reference proteome;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:25732537}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:25732537}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12185496; 18650403; 28936218; |
| Motif | |
| Gene Encoded By | |
| Mass | 54,982 |
| Kinetics | |
| Metal Binding | METAL 296; /note=Manganese 2; /evidence=ECO:0000255; METAL 307; /note=Manganese 1; /evidence=ECO:0000255; METAL 307; /note=Manganese 2; /evidence=ECO:0000255; METAL 383; /note=Manganese 1; /evidence=ECO:0000255; METAL 410; /note=Manganese 1; /evidence=ECO:0000255; METAL 433; /note=Manganese 1; /evidence=ECO:0000255; METAL 433; /note=Manganese 2; /evidence=ECO:0000255 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.11.26;3.4.24.59; |