| IED ID |
IndEnz0002007032 |
| Enzyme Type ID |
protease007032 |
| Protein Name |
Serine protease inhibitor Kazal-type 6
|
| Gene Name |
Spink6 |
| Organism |
Mus musculus (Mouse) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Glires (Rodents and rabbits)
Rodentia
Myomorpha (mice and others)
Muroidea
Muridae
Murinae
Mus
Mus
Mus musculus (Mouse)
|
| Enzyme Sequence |
MKVAGVFLLLSLALLCFFSGAFSQGGQDKRGWITRSEGRFPGKGVLRHRLFQINCGEFRDPKVFCTRESDPLCGSDGQTYGNKCAFCKALEKSSGKINLKHRGKC |
| Enzyme Length |
105 |
| Uniprot Accession Number |
Q8BT20 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK5 and human KLK2, KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit human KLK1 and KLK8. {ECO:0000269|PubMed:24352040}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (3); Domain (1); Modified residue (1); Signal peptide (1); Site (1) |
| Keywords |
Disulfide bond;Protease inhibitor;Pyrrolidone carboxylic acid;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
INDUCTION: Release of soluble SPINK6 is down-regulated by TNF-alpha. IFN-gamma and retinoic acid. Expression is reduced after mechanical and metabolic injury to the skin barrier. {ECO:0000269|PubMed:24352040}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24352040}. |
| Modified Residue |
MOD_RES 24; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000250|UniProtKB:P01001 |
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
20562862;
21677750;
|
| Motif |
|
| Gene Encoded By |
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| Mass |
11,609 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
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| Cross Reference Brenda |
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