| IED ID | IndEnz0002007097 |
| Enzyme Type ID | protease007097 |
| Protein Name |
Cathepsin B EC 3.4.22.1 Cathepsin B1 |
| Gene Name | ctsB DDB_G0283921 |
| Organism | Dictyostelium discoideum (Slime mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Eumycetozoa Dictyostelia (dictyostelid cellular slime molds) Dictyosteliales Dictyosteliaceae Dictyostelium Dictyostelium discoideum (Slime mold) |
| Enzyme Sequence | MRVLLSLVVILFIINSAFAVKINIGRPTKSHKTIHHETWVEEQTDQFDNIKVGQLLGFKRSPNRPKLQIKSYDPLGVQIPTSFNAQTNWPNCTTISQIQNQARCGSCWAFGATESATDRLCIHNNENVQLSFMDMVTCDETDNGCEGGDAFSAWNWLRKQGAVSEECLPYTIPTCPPAQQPCLNFVNTPSCTKECQSNSSLIYSQDKHKMAKIYSFDSDEAIMQEIVTNGPVEACFTVFEDFLAYKSGVYVHTTGKDLGGHCVKLVGFGTLNGVDYYAANNQWTTSWGDNGTFLIKRGDCGISDDVVAGLP |
| Enzyme Length | 311 |
| Uniprot Accession Number | Q54QD9 |
| Absorption | |
| Active Site | ACT_SITE 107; /evidence=ECO:0000250; ACT_SITE 261; /evidence=ECO:0000250; ACT_SITE 281; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.; EC=3.4.22.1; |
| DNA Binding | |
| EC Number | 3.4.22.1 |
| Enzyme Function | FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (5); Glycosylation (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Lysosome;Protease;Reference proteome;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Lysosome {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 18559084; 20422638; 22120990; |
| Motif | |
| Gene Encoded By | |
| Mass | 34,437 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |